Compare GO annotations for HomoloGene:1148 orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, fly, worm, tair, rice, yeast, pombe, pfalc, zfin.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Fly from Flybase; Worm from Wormbase; Tair from TAIR; Rice from Gramene; Yeast from SGD; Pombe from S.pombe Genome Project; Pfalc from PlasmoDB; Zfin from Zfin.
Organisms with experimental annotations are indicated: IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IC, IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Tue Sep 18 15:47:31 2007.

Category	ID	Term	DB Object	DB Symbol	Evidence	Organism	Reference
Molecular Function	GO:0043531	ADP binding	P48506	GSH1_HUMAN	IDA	Human	PMID:24639
Molecular Function	GO:0043531	ADP binding	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Molecular Function	GO:0050662	coenzyme binding	P48506	GSH1_HUMAN	IPI	Human	PMID:9841880
Molecular Function	GO:0050662	coenzyme binding	P48506	GSH1_HUMAN	IPI	Human	PMID:9675072
Molecular Function	GO:0050662	coenzyme binding	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Molecular Function	GO:0016595	glutamate binding	P48506	GSH1_HUMAN	IDA	Human	PMID:9841880
Molecular Function	GO:0016595	glutamate binding	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	P48506	GSH1_HUMAN	IDA	Human	PMID:8104187
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	P48506	GSH1_HUMAN	IMP	Human	PMID:16183645
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	P48506	GSH1_HUMAN	IDA	Human	PMID:11972604
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	MGI:104990	Gclc	IDA	Mouse	MGI:MGI:2157601\|PMID:10966520
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	MGI:104990	Gclc	IDA	Mouse	MGI:MGI:2447526\|PMID:12384496
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	MGI:104990	Gclc	IDA	Mouse	MGI:MGI:3047441\|PMID:15288121
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	MGI:104990	Gclc	IDA	Mouse	MGI:MGI:3607629\|PMID:16081425
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	MGI:104990	Gclc	IMP	Mouse	MGI:MGI:1928560\|PMID:11118286
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	RGD:619868	Gclc	ISS	Rat	RGD:1358708\|PMID:8825659
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	RGD:619868	Gclc	ISS	Rat	RGD:1580654
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	RGD:619868	Gclc	ISS	Rat	RGD:1580655
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	RGD:619868	Gclc	IMP	Rat	RGD:1582661\|PMID:16183645
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	FBgn0040319	Gclc	ISS	Fly	FB:FBrf0105495
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	FBgn0040319	Gclc	IDA	Fly	FB:FBrf0125293\|PMID:10675565
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	FBgn0040319	Gclc	ISS	Fly	FB:FBrf0125293\|PMID:10675565
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	FBgn0040319	Gclc	IDA	Fly	FB:FBrf0141591\|PMID:11698394
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	S000003637	GSH1	IMP	Yeast	SGD_REF:S000052673\|PMID:2184310
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	S000003637	GSH1	IDA	Yeast	SGD_REF:S000040589\|PMID:1687097
Molecular Function	GO:0004357	glutamate-cysteine ligase activity	SPAC22F3.10c	gcs1	IMP	Pombe	PMID:8619315
Molecular Function	GO:0000287	magnesium ion binding	P48506	GSH1_HUMAN	IDA	Human	PMID:24639
Molecular Function	GO:0000287	magnesium ion binding	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Molecular Function	GO:0005515	protein binding	FBgn0040319	Gclc	IPI	Fly	FB:FBrf0141591\|PMID:11698394
Molecular Function	GO:0005515	protein binding	FBgn0040319	Gclc	IPI	Fly	FB:FBrf0167749\|PMID:12954617
Molecular Function	GO:0046982	protein heterodimerization activity	MGI:104990	Gclc	IPI	Mouse	MGI:MGI:2447526\|PMID:12384496
Molecular Function	GO:0046982	protein heterodimerization activity	MGI:104990	Gclc	IPI	Mouse	MGI:MGI:3607629\|PMID:16081425
Molecular Function	GO:0046982	protein heterodimerization activity	RGD:619868	Gclc	IDA	Rat	RGD:1582663\|PMID:16137247
Cellular Component	GO:0005829	cytosol	MGI:104990	Gclc	IDA	Mouse	MGI:MGI:2447526\|PMID:12384496
Cellular Component	GO:0005829	cytosol	SPAC22F3.10c	gcs1	IDA	Pombe	PMID:16823372
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	MGI:104990	Gclc	IDA	Mouse	MGI:MGI:2447526\|PMID:12384496
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	RGD:619868	Gclc	IDA	Rat	RGD:1582663\|PMID:16137247
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	FBgn0040319	Gclc	ISS	Fly	FB:FBrf0105495
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	FBgn0040319	Gclc	IPI	Fly	FB:FBrf0141591\|PMID:11698394
Cellular Component	GO:0017109	glutamate-cysteine ligase complex	SPAC22F3.10c	gcs1	ISS	Pombe	GOC:unpublished
Cellular Component	GO:0005622	intracellular	S000003637	GSH1	IDA	Yeast	SGD_REF:S000052673\|PMID:2184310
Cellular Component	GO:0005634	nucleus	SPAC22F3.10c	gcs1	IDA	Pombe	PMID:16823372
Biological Process	GO:0006916	anti-apoptosis	P48506	GSH1_HUMAN	IDA	Human	PMID:10439045
Biological Process	GO:0006916	anti-apoptosis	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0008015	circulation	RGD:619868	Gclc	ISS	Rat	RGD:1358709\|PMID:2294991
Biological Process	GO:0008015	circulation	RGD:619868	Gclc	ISS	Rat	RGD:1580655
Biological Process	GO:0006534	cysteine metabolic process	P48506	GSH1_HUMAN	IDA	Human	PMID:2294991
Biological Process	GO:0006534	cysteine metabolic process	RGD:619868	Gclc	ISS	Rat	RGD:1358709\|PMID:2294991
Biological Process	GO:0006534	cysteine metabolic process	RGD:619868	Gclc	ISS	Rat	RGD:1580655
Biological Process	GO:0006534	cysteine metabolic process	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0006536	glutamate metabolic process	P48506	GSH1_HUMAN	IDA	Human	PMID:2294991
Biological Process	GO:0006536	glutamate metabolic process	P48506	GSH1_HUMAN	IDA	Human	PMID:12663448
Biological Process	GO:0006536	glutamate metabolic process	RGD:619868	Gclc	ISS	Rat	RGD:1358709\|PMID:2294991
Biological Process	GO:0006536	glutamate metabolic process	RGD:619868	Gclc	ISS	Rat	RGD:1580655
Biological Process	GO:0006536	glutamate metabolic process	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0006750	glutathione biosynthetic process	P48506	GSH1_HUMAN	IDA	Human	PMID:8104187
Biological Process	GO:0006750	glutathione biosynthetic process	P48506	GSH1_HUMAN	IDA	Human	PMID:10395918
Biological Process	GO:0006750	glutathione biosynthetic process	P48506	GSH1_HUMAN	IMP	Human	PMID:12663448
Biological Process	GO:0006750	glutathione biosynthetic process	MGI:104990	Gclc	IMP	Mouse	MGI:MGI:1858542\|PMID:10805773
Biological Process	GO:0006750	glutathione biosynthetic process	MGI:104990	Gclc	IDA	Mouse	MGI:MGI:3607629\|PMID:16081425
Biological Process	GO:0006750	glutathione biosynthetic process	RGD:619868	Gclc	ISS	Rat	RGD:632745\|PMID:1967255
Biological Process	GO:0006750	glutathione biosynthetic process	RGD:619868	Gclc	IMP	Rat	RGD:1582661\|PMID:16183645
Biological Process	GO:0006750	glutathione biosynthetic process	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0006750	glutathione biosynthetic process	FBgn0040319	Gclc	IDA	Fly	FB:FBrf0125293\|PMID:10675565
Biological Process	GO:0006750	glutathione biosynthetic process	FBgn0040319	Gclc	IDA	Fly	FB:FBrf0141591\|PMID:11698394
Biological Process	GO:0006750	glutathione biosynthetic process	WBGene00001527	gcs-1	IMP	Worm	WB:WBPaper00026968\|PMID:16333752
Biological Process	GO:0006750	glutathione biosynthetic process	S000003637	GSH1	IMP	Yeast	SGD_REF:S000049527\|PMID:8768524
Biological Process	GO:0006750	glutathione biosynthetic process	S000003637	GSH1	IDA	Yeast	SGD_REF:S000040589\|PMID:1687097
Biological Process	GO:0006750	glutathione biosynthetic process	SPAC22F3.10c	gcs1	IMP	Pombe	PMID:8619315
Biological Process	GO:0006749	glutathione metabolic process	MGI:104990	Gclc	IMP	Mouse	MGI:MGI:1928560\|PMID:11118286
Biological Process	GO:0019852	L-ascorbic acid metabolic process	MGI:104990	Gclc	IMP	Mouse	MGI:MGI:1928560\|PMID:11118286
Biological Process	GO:0043066	negative regulation of apoptosis	MGI:104990	Gclc	IGI	Mouse	MGI:MGI:3047441\|PMID:15288121
Biological Process	GO:0043524	negative regulation of neuron apoptosis	RGD:619868	Gclc	IMP	Rat	RGD:1582661\|PMID:16183645
Biological Process	GO:0031397	negative regulation of protein ubiquitination	MGI:104990	Gclc	IMP	Mouse	MGI:MGI:3695876\|PMID:17189825
Biological Process	GO:0016481	negative regulation of transcription	P48506	GSH1_HUMAN	IDA	Human	PMID:10439045
Biological Process	GO:0016481	negative regulation of transcription	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	MGI:104990	Gclc	IMP	Mouse	MGI:MGI:3695876\|PMID:17189825
Biological Process	GO:0050880	regulation of blood vessel size	P48506	GSH1_HUMAN	IMP	Human	PMID:12598062
Biological Process	GO:0050880	regulation of blood vessel size	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0030503	regulation of cell redox homeostasis	P48506	GSH1_HUMAN	IDA	Human	PMID:10439045
Biological Process	GO:0030503	regulation of cell redox homeostasis	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0051900	regulation of mitochondrial depolarization	MGI:104990	Gclc	IGI	Mouse	MGI:MGI:3047441\|PMID:15288121
Biological Process	GO:0046685	response to arsenic	MGI:104990	Gclc	IMP	Mouse	MGI:MGI:3695876\|PMID:17189825
Biological Process	GO:0046685	response to arsenic	WBGene00001527	gcs-1	IMP	Worm	WB:WBPaper00026968\|PMID:16333752
Biological Process	GO:0046686	response to cadmium ion	S000003637	GSH1	IEP	Yeast	SGD_REF:S000056170\|PMID:9044254
Biological Process	GO:0046686	response to cadmium ion	S000003637	GSH1	IDA	Yeast	SGD_REF:S000059727\|PMID:10921921
Biological Process	GO:0046686	response to cadmium ion	SPAC22F3.10c	gcs1	IMP	Pombe	PMID:8619315
Biological Process	GO:0009409	response to cold	S000003637	GSH1	IEP	Yeast	SGD_REF:S000073700\|PMID:12859956
Biological Process	GO:0042493	response to drug	S000003637	GSH1	IMP	Yeast	SGD_REF:S000086944\|PMID:16234568
Biological Process	GO:0009408	response to heat	P48506	GSH1_HUMAN	IDA	Human	PMID:8104187
Biological Process	GO:0009408	response to heat	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0009408	response to heat	WBGene00001527	gcs-1	IEP	Worm	WB:WBPaper00006024\|PMID:12869585
Biological Process	GO:0009408	response to heat	S000003637	GSH1	IEP	Yeast	SGD_REF:S000050112\|PMID:10809786
Biological Process	GO:0009635	response to herbicide	WBGene00001527	gcs-1	IEP	Worm	WB:WBPaper00006024\|PMID:12869585
Biological Process	GO:0009725	response to hormone stimulus	P48506	GSH1_HUMAN	IDA	Human	PMID:8104187
Biological Process	GO:0009725	response to hormone stimulus	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0042542	response to hydrogen peroxide	S000003637	GSH1	IEP	Yeast	SGD_REF:S000056170\|PMID:9044254
Biological Process	GO:0042542	response to hydrogen peroxide	S000003637	GSH1	IMP	Yeast	SGD_REF:S000063336\|PMID:7615092
Biological Process	GO:0046689	response to mercury ion	S000003637	GSH1	IEP	Yeast	SGD_REF:S000069228\|PMID:11816031
Biological Process	GO:0051409	response to nitrosative stress	RGD:619868	Gclc	IMP	Rat	RGD:1582661\|PMID:16183645
Biological Process	GO:0006979	response to oxidative stress	P48506	GSH1_HUMAN	IDA	Human	PMID:11972604
Biological Process	GO:0006979	response to oxidative stress	P48506	GSH1_HUMAN	IDA	Human	PMID:10395918
Biological Process	GO:0006979	response to oxidative stress	RGD:619868	Gclc	IMP	Rat	RGD:1582661\|PMID:16183645
Biological Process	GO:0006979	response to oxidative stress	RGD:619868	Gclc	ISS	Rat	RGD:1600115
Biological Process	GO:0009410	response to xenobiotic stimulus	MGI:104990	Gclc	IMP	Mouse	MGI:MGI:3695876\|PMID:17189825

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)