Compare GO annotations for HomoloGene:2467 orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, fly, worm, tair, rice, yeast, pombe, pfalc, zfin.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Fly from Flybase; Worm from Wormbase; Tair from TAIR; Rice from Gramene; Yeast from SGD; Pombe from S.pombe Genome Project; Pfalc from PlasmoDB; Zfin from Zfin.
Organisms with experimental annotations are indicated: IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IC, IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Tue Sep 18 15:47:31 2007.

Category	ID	Term	DB Object	DB Symbol	Evidence	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	P11387	TOP1_HUMAN	IDA	Human	PMID:9049244
Molecular Function	GO:0003682	chromatin binding	P79994	P79994_CHICK	ISS	Chicken	UniProt:P79994
Molecular Function	GO:0031490	chromatin DNA binding	RGD:621246	Top1	IDA	Rat	RGD:1580856\|PMID:1332866
Molecular Function	GO:0003677	DNA binding	P79994	P79994_CHICK	ISS	Chicken	UniProt:P79994
Molecular Function	GO:0003917	DNA topoisomerase type I activity	P11387	TOP1_HUMAN	IMP	Human	PMID:17355975
Molecular Function	GO:0003917	DNA topoisomerase type I activity	MGI:98788	Top1	IDA	Mouse	MGI:MGI:3612364\|PMID:16261531
Molecular Function	GO:0003917	DNA topoisomerase type I activity	MGI:98788	Top1	IDA	Mouse	MGI:MGI:86770\|PMID:9094096
Molecular Function	GO:0003917	DNA topoisomerase type I activity	MGI:98788	Top1	IDA	Mouse	MGI:MGI:70738\|PMID:7842491
Molecular Function	GO:0003917	DNA topoisomerase type I activity	RGD:621246	Top1	ISS	Rat	RGD:1302321\|PMID:13679149
Molecular Function	GO:0003917	DNA topoisomerase type I activity	RGD:621246	Top1	ISS	Rat	RGD:1580655
Molecular Function	GO:0003917	DNA topoisomerase type I activity	RGD:621246	Top1	IDA	Rat	RGD:1580856\|PMID:1332866
Molecular Function	GO:0003917	DNA topoisomerase type I activity	P79994	P79994_CHICK	ISS	Chicken	UniProt:P79994
Molecular Function	GO:0003917	DNA topoisomerase type I activity	FBgn0004924	Top1	IDA	Fly	FB:FBrf0038563\|PMID:6294622
Molecular Function	GO:0003917	DNA topoisomerase type I activity	FBgn0004924	Top1	ISS	Fly	FB:FBrf0105495
Molecular Function	GO:0003917	DNA topoisomerase type I activity	WB:WP:CE12282	TOP-1	IDA	Worm	WB:WBPaper00002435\|PMID:8647074
Molecular Function	GO:0003917	DNA topoisomerase type I activity	WB:WP:CE12284	TOP-1	IDA	Worm	WB:WBPaper00002435\|PMID:8647074
Molecular Function	GO:0003917	DNA topoisomerase type I activity	gene:3715992	TOP1alpha	IGI	Tair	TAIR:Publication:501676135
Molecular Function	GO:0003917	DNA topoisomerase type I activity	S000005366	TOP1	IMP	Yeast	SGD_REF:S000055801\|PMID:2989818
Molecular Function	GO:0003917	DNA topoisomerase type I activity	S000005366	TOP1	IDA	Yeast	SGD_REF:S000058487\|PMID:6088500
Molecular Function	GO:0003917	DNA topoisomerase type I activity	SPBC1703.14c	top1	ISS	Pombe	GOC:unpublished
Molecular Function	GO:0005515	protein binding	P11387	TOP1_HUMAN	IPI	Human	PMID:10352183
Molecular Function	GO:0005515	protein binding	P79994	P79994_CHICK	ISS	Chicken	UniProt:P79994
Cellular Component	GO:0005694	chromosome	P11387	TOP1_HUMAN	IDA	Human	PMID:9049244
Cellular Component	GO:0005694	chromosome	P79994	P79994_CHICK	ISS	Chicken	UniProt:P79994
Cellular Component	GO:0005737	cytoplasm	MGI:98788	Top1	IDA	Mouse	MGI:MGI:3612364\|PMID:16261531
Cellular Component	GO:0005737	cytoplasm	FBgn0004924	Top1	IDA	Fly	FB:FBrf0128696\|PMID:10885744
Cellular Component	GO:0005730	nucleolus	P11387	TOP1_HUMAN	IDA	Human	PMID:9049244
Cellular Component	GO:0005730	nucleolus	P79994	P79994_CHICK	ISS	Chicken	UniProt:P79994
Cellular Component	GO:0005730	nucleolus	WB:WP:CE12282	TOP-1	IDA	Worm	WB:WBPaper00004689\|PMID:11318873
Cellular Component	GO:0005730	nucleolus	WB:WP:CE12284	TOP-1	IDA	Worm	WB:WBPaper00004689\|PMID:11318873
Cellular Component	GO:0005730	nucleolus	S000005366	TOP1	IPI	Yeast	SGD_REF:S000051297\|PMID:10967121
Cellular Component	GO:0005730	nucleolus	SPBC1703.14c	top1	IDA	Pombe	PMID:16823372
Cellular Component	GO:0005654	nucleoplasm	P11387	TOP1_HUMAN	IDA	Human	PMID:9049244
Cellular Component	GO:0005654	nucleoplasm	P79994	P79994_CHICK	ISS	Chicken	UniProt:P79994
Cellular Component	GO:0005634	nucleus	P11387	TOP1_HUMAN	IDA	Human	PMID:9049244
Cellular Component	GO:0005634	nucleus	MGI:98788	Top1	IDA	Mouse	MGI:MGI:3612364\|PMID:16261531
Cellular Component	GO:0005634	nucleus	MGI:98788	Top1	ISS	Mouse	MGI:MGI:2154458
Cellular Component	GO:0005634	nucleus	MGI:98788	Top1	IDA	Mouse	MGI:MGI:86770\|PMID:9094096
Cellular Component	GO:0005634	nucleus	MGI:98788	Top1	IDA	Mouse	MGI:MGI:83974\|PMID:8943335
Cellular Component	GO:0005634	nucleus	RGD:621246	Top1	IDA	Rat	RGD:1580856\|PMID:1332866
Cellular Component	GO:0005634	nucleus	P79994	P79994_CHICK	ISS	Chicken	UniProt:P79994
Cellular Component	GO:0005634	nucleus	FBgn0004924	Top1	IDA	Fly	FB:FBrf0038563\|PMID:6294622
Cellular Component	GO:0005634	nucleus	FBgn0004924	Top1	IDA	Fly	FB:FBrf0128696\|PMID:10885744
Cellular Component	GO:0005634	nucleus	WB:WP:CE12282	TOP-1	IDA	Worm	WB:WBPaper00004689\|PMID:11318873
Cellular Component	GO:0005634	nucleus	WB:WP:CE12284	TOP-1	IDA	Worm	WB:WBPaper00004689\|PMID:11318873
Cellular Component	GO:0005634	nucleus	S000005366	TOP1	IDA	Yeast	SGD_REF:S000058487\|PMID:6088500
Cellular Component	GO:0005634	nucleus	SPBC1703.14c	top1	ISS	Pombe	GOC:unpublished
Cellular Component	GO:0005634	nucleus	SPBC1703.14c	top1	IDA	Pombe	PMID:16823372
Cellular Component	GO:0043204	perikaryon	MGI:98788	Top1	IDA	Mouse	MGI:MGI:3612364\|PMID:16261531
Cellular Component	GO:0031616	spindle pole centrosome	WB:WP:CE12282	TOP-1	IDA	Worm	WB:WBPaper00004689\|PMID:11318873
Cellular Component	GO:0031616	spindle pole centrosome	WB:WP:CE12284	TOP-1	IDA	Worm	WB:WBPaper00004689\|PMID:11318873
Biological Process	GO:0008150	biological_process	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0008283	cell proliferation	FBgn0004924	Top1	IMP	Fly	FB:FBrf0128696\|PMID:10885744
Biological Process	GO:0006333	chromatin assembly or disassembly	S000005366	TOP1	IMP	Yeast	SGD_REF:S000052145\|PMID:9199287
Biological Process	GO:0006333	chromatin assembly or disassembly	SPBC1703.14c	top1	ISS	Pombe	GOC:unpublished
Biological Process	GO:0000183	chromatin silencing at rDNA	S000005366	TOP1	IMP	Yeast	SGD_REF:S000054483\|PMID:10082585
Biological Process	GO:0030261	chromosome condensation	FBgn0004924	Top1	IMP	Fly	FB:FBrf0128696\|PMID:10885744
Biological Process	GO:0007059	chromosome segregation	FBgn0004924	Top1	IMP	Fly	FB:FBrf0128696\|PMID:10885744
Biological Process	GO:0007059	chromosome segregation	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00004402\|PMID:11099033
Biological Process	GO:0006260	DNA replication	MGI:98788	Top1	IMP	Mouse	MGI:MGI:2157189\|PMID:11756244
Biological Process	GO:0006260	DNA replication	RGD:621246	Top1	ISS	Rat	RGD:1580654
Biological Process	GO:0006271	DNA strand elongation during DNA replication	S000005366	TOP1	IMP	Yeast	SGD_REF:S000051896\|PMID:2549254
Biological Process	GO:0006265	DNA topological change	MGI:98788	Top1	IDA	Mouse	MGI:MGI:70738\|PMID:7842491
Biological Process	GO:0006265	DNA topological change	MGI:98788	Top1	IDA	Mouse	MGI:MGI:3612364\|PMID:16261531
Biological Process	GO:0006265	DNA topological change	RGD:621246	Top1	IDA	Rat	RGD:1580856\|PMID:1332866
Biological Process	GO:0006265	DNA topological change	FBgn0004924	Top1	IDA	Fly	FB:FBrf0038563\|PMID:6294622
Biological Process	GO:0006265	DNA topological change	gene:3715992	TOP1alpha	ISS	Tair	TAIR:Publication:501676135
Biological Process	GO:0006265	DNA topological change	S000005366	TOP1	IMP	Yeast	SGD_REF:S000055801\|PMID:2989818
Biological Process	GO:0006265	DNA topological change	S000005366	TOP1	IDA	Yeast	SGD_REF:S000058487\|PMID:6088500
Biological Process	GO:0006265	DNA topological change	SPBC1703.14c	top1	IMP	Pombe	PMID:6090122
Biological Process	GO:0040016	embryonic cleavage	MGI:98788	Top1	IMP	Mouse	MGI:MGI:83974\|PMID:8943335
Biological Process	GO:0009790	embryonic development	FBgn0004924	Top1	IMP	Fly	FB:FBrf0128696\|PMID:10885744
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00024925\|PMID:15687288
Biological Process	GO:0006325	establishment and/or maintenance of chromatin architecture	SPBC1703.14c	top1	IGI	Pombe	PMID:6090122
Biological Process	GO:0048439	flower morphogenesis	gene:3715992	TOP1alpha	IMP	Tair	TAIR:Publication:501682361\|PMID:12215507
Biological Process	GO:0007276	gamete generation	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0008406	gonad development	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00004689\|PMID:11318873
Biological Process	GO:0040007	growth	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0002168	instar larval development	FBgn0004924	Top1	IMP	Fly	FB:FBrf0128696\|PMID:10885744
Biological Process	GO:0002119	larval development (sensu Nematoda)	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0007626	locomotory behavior	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0007076	mitotic chromosome condensation	S000005366	TOP1	IGI	Yeast	SGD_REF:S000043188\|PMID:8895658
Biological Process	GO:0007076	mitotic chromosome condensation	S000005366	TOP1	IMP	Yeast	SGD_REF:S000043188\|PMID:8895658
Biological Process	GO:0007076	mitotic chromosome condensation	SPBC1703.14c	top1	ISS	Pombe	GOC:unpublished
Biological Process	GO:0018988	molting cycle, protein-based cuticle	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00004402\|PMID:11099033
Biological Process	GO:0002009	morphogenesis of an epithelium	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00004402\|PMID:11099033
Biological Process	GO:0007275	multicellular organismal development	FBgn0004924	Top1	IMP	Fly	FB:FBrf0059286\|PMID:8393572
Biological Process	GO:0007097	nuclear migration	S000005366	TOP1	IMP	Yeast	SGD_REF:S000043188\|PMID:8895658
Biological Process	GO:0007097	nuclear migration	S000005366	TOP1	IGI	Yeast	SGD_REF:S000043188\|PMID:8895658
Biological Process	GO:0006289	nucleotide-excision repair	RGD:621246	Top1	ISS	Rat	RGD:1302321\|PMID:13679149
Biological Process	GO:0007308	oocyte construction	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00004689\|PMID:11318873
Biological Process	GO:0048645	organ formation	gene:3715992	TOP1alpha	IMP	Tair	TAIR:Publication:501682361\|PMID:12215507
Biological Process	GO:0040018	positive regulation of body size	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0040010	positive regulation of growth rate	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0000019	regulation of mitotic recombination	S000005366	TOP1	IMP	Yeast	SGD_REF:S000052967\|PMID:2902925
Biological Process	GO:0006357	regulation of transcription from RNA polymerase II promoter	S000005366	TOP1	IMP	Yeast	SGD_REF:S000044098\|PMID:1660829
Biological Process	GO:0000003	reproduction	WBGene00006595	top-1	IMP	Worm	WB:WBPaper00004689\|PMID:11318873
Biological Process	GO:0042493	response to drug	P11387	TOP1_HUMAN	IEP	Human	PMID:16127745
Biological Process	GO:0006368	RNA elongation from RNA polymerase II promoter	S000005366	TOP1	IMP	Yeast	SGD_REF:S000053282\|PMID:2840207
Biological Process	GO:0010016	shoot morphogenesis	gene:3715992	TOP1alpha	IMP	Tair	TAIR:Publication:501682361\|PMID:12215507
Biological Process	GO:0042790	transcription of nuclear rRNA large RNA polymerase I transcript	SPBC1703.14c	top1	IGI	Pombe	PMID:2839305

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)