Compare GO annotations for HomoloGene:265 orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, fly, worm, tair, rice, yeast, pombe, pfalc, zfin.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Fly from Flybase; Worm from Wormbase; Tair from TAIR; Rice from Gramene; Yeast from SGD; Pombe from S.pombe Genome Project; Pfalc from PlasmoDB; Zfin from Zfin.
Organisms with experimental annotations are indicated: IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IC, IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Tue Sep 18 15:47:31 2007.

Category	ID	Term	DB Object	DB Symbol	Evidence	Organism	Reference
Molecular Function	GO:0003779	actin binding	FBgn0026379	Pten	ISS	Fly	FB:FBrf0132100\|PMID:10908588
Molecular Function	GO:0004437	inositol or phosphatidylinositol phosphatase activity	RGD:61995	Pten	ISS	Rat	RGD:70315\|PMID:10581415
Molecular Function	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	P60484	PTEN_HUMAN	IDA	Human	PMID:9593664
Molecular Function	GO:0042577	lipid phosphatase activity	ZDB-GENE-030131-3776	ptena	IMP	Zfin	ZFIN:ZDB-PUB-050930-12\|PMID:16193492
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	FBgn0026379	Pten	ISS	Fly	FB:FBrf0111917\|PMID:10556061
Molecular Function	GO:0030165	PDZ domain binding	P60484	PTEN_HUMAN	IPI	Human	PMID:10646847
Molecular Function	GO:0030165	PDZ domain binding	P60484	PTEN_HUMAN	IPI	Human	PMID:10760291
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	P60484	PTEN_HUMAN	IDA	Human	PMID:9593664
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	P60484	PTEN_HUMAN	IDA	Human	PMID:9811831
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	MGI:109583	Pten	IDA	Mouse	MGI:MGI:2180890\|PMID:9778245
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	RGD:61995	Pten	ISS	Rat	RGD:1580654
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	FBgn0026379	Pten	IGI	Fly	FB:FBrf0123020\|PMID:10617573
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	FBgn0026379	Pten	ISS	Fly	FB:FBrf0123020\|PMID:10617573
Molecular Function	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	P60484	PTEN_HUMAN	IDA	Human	PMID:9811831
Molecular Function	GO:0004438	phosphatidylinositol-3-phosphatase activity	P60484	PTEN_HUMAN	IDA	Human	PMID:9811831
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	FBgn0026379	Pten	IMP	Fly	FB:FBrf0111917\|PMID:10556061
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	FBgn0026379	Pten	ISS	Fly	FB:FBrf0123020\|PMID:10617573
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	RGD:61995	Pten	IDA	Rat	RGD:1358422\|PMID:14718524
Molecular Function	GO:0005515	protein binding	P60484	PTEN_HUMAN	IPI	Human	PMID:15951562
Molecular Function	GO:0005515	protein binding	P60484	PTEN_HUMAN	IPI	Human	PMID:17218262
Molecular Function	GO:0005515	protein binding	P60484	PTEN_HUMAN	IPI	Human	PMID:17274640
Molecular Function	GO:0005515	protein binding	MGI:109583	Pten	IPI	Mouse	MGI:MGI:3706446\|PMID:17218262
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	P60484	PTEN_HUMAN	IDA	Human	PMID:9256433
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	FBgn0026379	Pten	IMP	Fly	FB:FBrf0195575\|PMID:15808505
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	P60484	PTEN_HUMAN	IDA	Human	PMID:9256433
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	FBgn0026379	Pten	ISS	Fly	FB:FBrf0141274
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	FBgn0026379	Pten	ISS	Fly	FB:FBrf0111917\|PMID:10556061
Cellular Component	GO:0005737	cytoplasm	P60484	PTEN_HUMAN	IDA	Human	PMID:9187108
Biological Process	GO:0030036	actin cytoskeleton organization and biogenesis	FBgn0026379	Pten	IMP	Fly	FB:FBrf0183928\|PMID:15743877
Biological Process	GO:0007015	actin filament organization	FBgn0026379	Pten	IMP	Fly	FB:FBrf0167741\|PMID:14527345
Biological Process	GO:0001525	angiogenesis	MGI:109583	Pten	IMP	Mouse	MGI:MGI:3588627\|PMID:16107612
Biological Process	GO:0006915	apoptosis	FBgn0026379	Pten	IMP	Fly	FB:FBrf0111917\|PMID:10556061
Biological Process	GO:0006914	autophagy	FBgn0026379	Pten	IMP	Fly	FB:FBrf0180118\|PMID:15296715
Biological Process	GO:0001568	blood vessel development	ZDB-GENE-030131-3776	ptena	IMP	Zfin	ZFIN:ZDB-PUB-050930-12\|PMID:16193492
Biological Process	GO:0048738	cardiac muscle development	MGI:109583	Pten	IMP	Mouse	MGI:MGI:3588627\|PMID:16107612
Biological Process	GO:0007155	cell adhesion	FBgn0026379	Pten	IMP	Fly	FB:FBrf0167741\|PMID:14527345
Biological Process	GO:0016477	cell migration	MGI:109583	Pten	IMP	Mouse	MGI:MGI:2181081\|PMID:12091320
Biological Process	GO:0016477	cell migration	RGD:61995	Pten	ISS	Rat	RGD:1580654
Biological Process	GO:0008283	cell proliferation	FBgn0026379	Pten	IMP	Fly	FB:FBrf0123020\|PMID:10617573
Biological Process	GO:0008283	cell proliferation	FBgn0026379	Pten	IMP	Fly	FB:FBrf0127089\|PMID:10790335
Biological Process	GO:0009987	cellular process	FBgn0026379	Pten	IMP	Fly	FB:FBrf0127089\|PMID:10790335
Biological Process	GO:0007417	central nervous system development	P60484	PTEN_HUMAN	ISS	Human	UniProt:P60484
Biological Process	GO:0007417	central nervous system development	MGI:109583	Pten	IMP	Mouse	MGI:MGI:2181081\|PMID:12091320
Biological Process	GO:0007417	central nervous system development	RGD:61995	Pten	ISS	Rat	RGD:1580654
Biological Process	GO:0007010	cytoskeleton organization and biogenesis	FBgn0026379	Pten	IMP	Fly	FB:FBrf0123020\|PMID:10617573
Biological Process	GO:0043542	endothelial cell migration	MGI:109583	Pten	IMP	Mouse	MGI:MGI:3588627\|PMID:16107612
Biological Process	GO:0007425	epithelial cell fate determination, open tracheal system	FBgn0026379	Pten	IMP	Fly	FB:FBrf0141466\|PMID:11740943
Biological Process	GO:0007507	heart development	P60484	PTEN_HUMAN	ISS	Human	UniProt:P60484
Biological Process	GO:0007507	heart development	MGI:109583	Pten	IMP	Mouse	MGI:MGI:3577662\|PMID:15755804
Biological Process	GO:0007507	heart development	RGD:61995	Pten	ISS	Rat	RGD:1580654
Biological Process	GO:0006917	induction of apoptosis	P60484	PTEN_HUMAN	ISS	Human	UniProt:P60484
Biological Process	GO:0006917	induction of apoptosis	MGI:109583	Pten	IMP	Mouse	MGI:MGI:2180890\|PMID:9778245
Biological Process	GO:0006917	induction of apoptosis	RGD:61995	Pten	ISS	Rat	RGD:1580654
Biological Process	GO:0046855	inositol phosphate dephosphorylation	P60484	PTEN_HUMAN	IDA	Human	PMID:9593664
Biological Process	GO:0046855	inositol phosphate dephosphorylation	RGD:61995	Pten	ISS	Rat	RGD:70315\|PMID:10581415
Biological Process	GO:0008286	insulin receptor signaling pathway	FBgn0026379	Pten	IGI	Fly	FB:FBrf0111917\|PMID:10556061
Biological Process	GO:0002164	larval development	FBgn0026379	Pten	IMP	Fly	FB:FBrf0190035\|PMID:16182527
Biological Process	GO:0007436	larval salivary gland morphogenesis	FBgn0026379	Pten	IMP	Fly	FB:FBrf0187400\|PMID:15963974
Biological Process	GO:0007552	metamorphosis	FBgn0026379	Pten	IMP	Fly	FB:FBrf0190035\|PMID:16182527
Biological Process	GO:0043066	negative regulation of apoptosis	MGI:109583	Pten	IMP	Mouse	MGI:MGI:2151077\|PMID:10339565
Biological Process	GO:0040015	negative regulation of body size	FBgn0026379	Pten	IMP	Fly	FB:FBrf0151278\|PMID:12163412
Biological Process	GO:0030336	negative regulation of cell migration	P60484	PTEN_HUMAN	IMP	Human	PMID:9616126
Biological Process	GO:0008285	negative regulation of cell proliferation	P60484	PTEN_HUMAN	IMP	Human	PMID:10468583
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:109583	Pten	IGI	Mouse	MGI:MGI:3586938\|PMID:16027168
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:109583	Pten	IMP	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0008285	negative regulation of cell proliferation	RGD:61995	Pten	IDA	Rat	RGD:1358424\|PMID:14656929
Biological Process	GO:0051895	negative regulation of focal adhesion formation	P60484	PTEN_HUMAN	IMP	Human	PMID:9616126
Biological Process	GO:0051898	negative regulation of protein kinase B signaling cascade	P60484	PTEN_HUMAN	IMP	Human	PMID:10760291
Biological Process	GO:0051898	negative regulation of protein kinase B signaling cascade	MGI:109583	Pten	IMP	Mouse	MGI:MGI:2151077\|PMID:10339565
Biological Process	GO:0031175	neurite development	RGD:61995	Pten	IDA	Rat	RGD:1358423\|PMID:14990793
Biological Process	GO:0009887	organ morphogenesis	FBgn0026379	Pten	IMP	Fly	FB:FBrf0127089\|PMID:10790335
Biological Process	GO:0031174	otolith mineralization (sensu Actinopterygii)	ZDB-GENE-030131-3776	ptena	IMP	Zfin	ZFIN:ZDB-PUB-050930-12\|PMID:16193492
Biological Process	GO:0046856	phosphoinositide dephosphorylation	P60484	PTEN_HUMAN	IDA	Human	PMID:9811831
Biological Process	GO:0046856	phosphoinositide dephosphorylation	P60484	PTEN_HUMAN	IDA	Human	PMID:9593664
Biological Process	GO:0046856	phosphoinositide dephosphorylation	ZDB-GENE-030131-3776	ptena	IMP	Zfin	ZFIN:ZDB-PUB-050930-12\|PMID:16193492
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	RGD:61995	Pten	IDA	Rat	RGD:1358422\|PMID:14718524
Biological Process	GO:0006470	protein amino acid dephosphorylation	P60484	PTEN_HUMAN	IDA	Human	PMID:9256433
Biological Process	GO:0006470	protein amino acid dephosphorylation	FBgn0026379	Pten	ISS	Fly	FB:FBrf0123020\|PMID:10617573
Biological Process	GO:0006470	protein amino acid dephosphorylation	FBgn0026379	Pten	IMP	Fly	FB:FBrf0195575\|PMID:15808505
Biological Process	GO:0040014	regulation of body size	FBgn0026379	Pten	IMP	Fly	FB:FBrf0190035\|PMID:16182527
Biological Process	GO:0008360	regulation of cell shape	FBgn0026379	Pten	IMP	Fly	FB:FBrf0123020\|PMID:10617573
Biological Process	GO:0008360	regulation of cell shape	FBgn0026379	Pten	IMP	Fly	FB:FBrf0167741\|PMID:14527345
Biological Process	GO:0008361	regulation of cell size	FBgn0026379	Pten	IMP	Fly	FB:FBrf0111917\|PMID:10556061
Biological Process	GO:0008361	regulation of cell size	FBgn0026379	Pten	IMP	Fly	FB:FBrf0123020\|PMID:10617573
Biological Process	GO:0051896	regulation of protein kinase B signaling cascade	ZDB-GENE-030131-3776	ptena	IMP	Zfin	ZFIN:ZDB-PUB-050930-12\|PMID:16193492
Biological Process	GO:0031647	regulation of protein stability	P60484	PTEN_HUMAN	IMP	Human	PMID:10866658
Biological Process	GO:0042594	response to starvation	FBgn0026379	Pten	IMP	Fly	FB:FBrf0151278\|PMID:12163412
Biological Process	GO:0009888	tissue development	FBgn0026379	Pten	IMP	Fly	FB:FBrf0127089\|PMID:10790335

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)