Compare GO annotations for HomoloGene:31310 orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, fly, worm, tair, rice, yeast, pombe, pfalc, zfin.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Fly from Flybase; Worm from Wormbase; Tair from TAIR; Rice from Gramene; Yeast from SGD; Pombe from S.pombe Genome Project; Pfalc from PlasmoDB; Zfin from Zfin.
Organisms with experimental annotations are indicated: IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IC, IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Tue Sep 18 15:47:31 2007.

Category	ID	Term	DB Object	DB Symbol	Evidence	Organism	Reference
Molecular Function	GO:0003677	DNA binding	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:2445266\|PMID:12270938
Molecular Function	GO:0003677	DNA binding	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:3487188\|PMID:15459107
Molecular Function	GO:0003677	DNA binding	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Molecular Function	GO:0003677	DNA binding	RGD:3033	Smad4	IDA	Rat	RGD:1599906\|PMID:16959941
Molecular Function	GO:0005515	protein binding	Q13485	SMAD4_HUMAN	IPI	Human	PMID:14525983
Molecular Function	GO:0005515	protein binding	Q13485	SMAD4_HUMAN	IPI	Human	PMID:16959612
Molecular Function	GO:0005515	protein binding	MGI:894293	Smad4	IPI	Mouse	MGI:MGI:2449899\|PMID:12543979
Molecular Function	GO:0005515	protein binding	MGI:894293	Smad4	IPI	Mouse	MGI:MGI:2682456\|PMID:14633973
Molecular Function	GO:0005515	protein binding	MGI:894293	Smad4	IPI	Mouse	MGI:MGI:3513643\|PMID:15282343
Molecular Function	GO:0005515	protein binding	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Molecular Function	GO:0005515	protein binding	RGD:3033	Smad4	ISS	Rat	RGD:1580655
Molecular Function	GO:0005515	protein binding	RGD:3033	Smad4	IDA	Rat	RGD:1599409\|PMID:15153551
Molecular Function	GO:0005515	protein binding	RGD:3033	Smad4	IPI	Rat	RGD:1599906\|PMID:16959941
Molecular Function	GO:0005515	protein binding	FBgn0011655	Med	IPI	Fly	FB:FBrf0102610\|PMID:9502724
Molecular Function	GO:0046332	SMAD binding	RGD:3033	Smad4	IPI	Rat	RGD:1599906\|PMID:16959941
Molecular Function	GO:0016563	transcription activator activity	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:3513643\|PMID:15282343
Molecular Function	GO:0016563	transcription activator activity	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Molecular Function	GO:0003712	transcription cofactor activity	RGD:3033	Smad4	ISS	Rat	RGD:1580655
Molecular Function	GO:0003700	transcription factor activity	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:2675699\|PMID:12943993
Molecular Function	GO:0003700	transcription factor activity	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:2682456\|PMID:14633973
Molecular Function	GO:0003700	transcription factor activity	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:3621084\|PMID:16556916
Molecular Function	GO:0003700	transcription factor activity	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Molecular Function	GO:0003700	transcription factor activity	RGD:3033	Smad4	ISS	Rat	RGD:1580655
Cellular Component	GO:0005737	cytoplasm	RGD:3033	Smad4	ISS	Rat	RGD:1580655
Cellular Component	GO:0005737	cytoplasm	RGD:3033	Smad4	IDA	Rat	RGD:1599901\|PMID:16570350
Cellular Component	GO:0005737	cytoplasm	FBgn0011655	Med	IDA	Fly	FB:FBrf0102610\|PMID:9502724
Cellular Component	GO:0005634	nucleus	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:2449899\|PMID:12543979
Cellular Component	GO:0005634	nucleus	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:2675699\|PMID:12943993
Cellular Component	GO:0005634	nucleus	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Cellular Component	GO:0005634	nucleus	RGD:3033	Smad4	ISS	Rat	RGD:1580655
Cellular Component	GO:0005634	nucleus	RGD:3033	Smad4	IDA	Rat	RGD:1599906\|PMID:16959941
Cellular Component	GO:0005634	nucleus	FBgn0011655	Med	IPI	Fly	FB:FBrf0102610\|PMID:9502724
Cellular Component	GO:0043234	protein complex	RGD:3033	Smad4	IDA	Rat	RGD:1599906\|PMID:16959941
Cellular Component	GO:0005667	transcription factor complex	Q13485	SMAD4_HUMAN	IPI	Human	PMID:12374795
Cellular Component	GO:0005667	transcription factor complex	MGI:894293	Smad4	IPI	Mouse	MGI:MGI:3694154\|PMID:9288972
Cellular Component	GO:0005667	transcription factor complex	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Biological Process	GO:0009952	anterior/posterior pattern formation	MGI:894293	Smad4	IMP	Mouse	MGI:MGI:3051711\|PMID:15215210
Biological Process	GO:0009952	anterior/posterior pattern formation	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Biological Process	GO:0008283	cell proliferation	FBgn0011655	Med	IMP	Fly	FB:FBrf0135803\|PMID:11290719
Biological Process	GO:0040024	dauer larval development	WBGene00004858	sma-4	IGI	Worm	WB:WBPaper00003400\|PMID:9847239
Biological Process	GO:0009950	dorsal/ventral axis specification	FBgn0011655	Med	IMP	Fly	FB:FBrf0102608\|PMID:9502722
Biological Process	GO:0009953	dorsal/ventral pattern formation	FBgn0011655	Med	IMP	Fly	FB:FBrf0102610\|PMID:9502724
Biological Process	GO:0010003	gastrulation (sensu Mammalia)	MGI:894293	Smad4	IMP	Mouse	MGI:MGI:3051711\|PMID:15215210
Biological Process	GO:0010003	gastrulation (sensu Mammalia)	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Biological Process	GO:0042078	germ-line stem cell division	FBgn0011655	Med	IMP	Fly	FB:FBrf0103396\|PMID:9695953
Biological Process	GO:0030718	germ-line stem cell maintenance	FBgn0011655	Med	IMP	Fly	FB:FBrf0103396\|PMID:9695953
Biological Process	GO:0007480	imaginal disc-derived leg morphogenesis	FBgn0011655	Med	IMP	Fly	FB:FBrf0135803\|PMID:11290719
Biological Process	GO:0007476	imaginal disc-derived wing morphogenesis	FBgn0011655	Med	IMP	Fly	FB:FBrf0135803\|PMID:11290719
Biological Process	GO:0001822	kidney development	MGI:894293	Smad4	IMP	Mouse	MGI:MGI:3623046\|PMID:15342483
Biological Process	GO:0002119	larval development (sensu Nematoda)	WBGene00004858	sma-4	IMP	Worm	WB:WBPaper00005567\|PMID:12397107
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:894293	Smad4	IGI	Mouse	MGI:MGI:3583399\|PMID:15925496
Biological Process	GO:0008285	negative regulation of cell proliferation	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Biological Process	GO:0048666	neuron development	FBgn0011655	Med	IMP	Fly	FB:FBrf0190369\|PMID:16437159
Biological Process	GO:0040018	positive regulation of body size	WBGene00004858	sma-4	IMP	Worm	WB:WBPaper00005654\|PMID:12529635
Biological Process	GO:0040018	positive regulation of body size	WBGene00004858	sma-4	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0040018	positive regulation of body size	WBGene00004858	sma-4	IGI	Worm	WB:WBPaper00005325\|PMID:12051826
Biological Process	GO:0040018	positive regulation of body size	WBGene00004858	sma-4	IMP	Worm	WB:WBPaper00005567\|PMID:12397107
Biological Process	GO:0040018	positive regulation of body size	WBGene00004858	sma-4	IMP	Worm	WB:WBPaper00005858\|PMID:12717735
Biological Process	GO:0045793	positive regulation of cell size	WBGene00004858	sma-4	IMP	Worm	WB:WBPaper00005567\|PMID:12397107
Biological Process	GO:0046622	positive regulation of organ size	WBGene00004858	sma-4	IMP	Worm	WB:WBPaper00005567\|PMID:12397107
Biological Process	GO:0045732	positive regulation of protein catabolic process	WBGene00004858	sma-4	IMP	Worm	WB:WBPaper00005567\|PMID:12397107
Biological Process	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	FBgn0011655	Med	IMP	Fly	FB:FBrf0175022\|PMID:15046722
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:1276222\|PMID:9702197
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:3621084\|PMID:16556916
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Biological Process	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:3513643\|PMID:15282343
Biological Process	GO:0045893	positive regulation of transcription, DNA-dependent	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Biological Process	GO:0051098	regulation of binding	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:3513643\|PMID:15282343
Biological Process	GO:0051098	regulation of binding	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Biological Process	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:894293	Smad4	IDA	Mouse	MGI:MGI:2445266\|PMID:12270938
Biological Process	GO:0006357	regulation of transcription from RNA polymerase II promoter	RGD:3033	Smad4	ISS	Rat	RGD:1580654
Biological Process	GO:0031290	retinal ganglion cell axon guidance	FBgn0011655	Med	IMP	Fly	FB:FBrf0187493\|PMID:16176948
Biological Process	GO:0007183	SMAD protein complex assembly	RGD:3033	Smad4	ISS	Rat	RGD:1580655
Biological Process	GO:0045138	tail tip morphogenesis (sensu Nematoda)	WBGene00004858	sma-4	IGI	Worm	WB:WBPaper00003400\|PMID:9847239
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	FBgn0011655	Med	IGI	Fly	FB:FBrf0102608\|PMID:9502722
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	FBgn0011655	Med	IMP	Fly	FB:FBrf0102608\|PMID:9502722
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	FBgn0011655	Med	ISS	Fly	FB:FBrf0102608\|PMID:9502722
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	FBgn0011655	Med	IGI	Fly	FB:FBrf0102610\|PMID:9502724
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	FBgn0011655	Med	IMP	Fly	FB:FBrf0135803\|PMID:11290719
Biological Process	GO:0001658	ureteric bud branching	MGI:894293	Smad4	IGI	Mouse	MGI:MGI:3583399\|PMID:15925496
Biological Process	GO:0001658	ureteric bud branching	RGD:3033	Smad4	ISS	Rat	RGD:1580654

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)