Compare GO annotations for HomoloGene:3557 orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, fly, worm, tair, rice, yeast, pombe, pfalc, zfin.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Fly from Flybase; Worm from Wormbase; Tair from TAIR; Rice from Gramene; Yeast from SGD; Pombe from S.pombe Genome Project; Pfalc from PlasmoDB; Zfin from Zfin.
Organisms with experimental annotations are indicated: IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IC, IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Tue Sep 18 15:47:31 2007.

Category	ID	Term	DB Object	DB Symbol	Evidence	Organism	Reference
Molecular Function	GO:0004686	eukaryotic elongation factor-2 kinase activity	FBgn0037327	PEK	ISS	Fly	FB:FBrf0105495
Molecular Function	GO:0004686	eukaryotic elongation factor-2 kinase activity	FBgn0037327	PEK	IDA	Fly	FB:FBrf0158918\|PMID:12605680
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Q9NZJ5	E2AK3_HUMAN	IMP	Human	PMID:12086964
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:11907036
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:10677345
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:10026192
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	RGD:70884	Eif2ak3	IMP	Rat	RGD:1581062\|PMID:15936177
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	RGD:70884	Eif2ak3	ISS	Rat	RGD:1600115
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	RGD:70884	Eif2ak3	IDA	Rat	RGD:70729\|PMID:9819435
Molecular Function	GO:0042802	identical protein binding	Q9NZJ5	E2AK3_HUMAN	IPI	Human	PMID:11907036
Molecular Function	GO:0005515	protein binding	MGI:1341830	Eif2ak3	IPI	Mouse	MGI:MGI:2677605\|PMID:14517290
Molecular Function	GO:0004672	protein kinase activity	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:2677605\|PMID:14517290
Molecular Function	GO:0004672	protein kinase activity	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3511630\|PMID:15542627
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:1333015\|PMID:9930704
Molecular Function	GO:0004674	protein serine/threonine kinase activity	RGD:70884	Eif2ak3	IDA	Rat	RGD:632569\|PMID:11781318
Molecular Function	GO:0004674	protein serine/threonine kinase activity	FBgn0037327	PEK	ISS	Fly	FB:FBrf0125266\|PMID:10677345
Molecular Function	GO:0004713	protein-tyrosine kinase activity	RGD:70884	Eif2ak3	ISS	Rat	RGD:1580654
Cellular Component	GO:0005623	cell	RGD:70884	Eif2ak3	IDA	Rat	RGD:70729\|PMID:9819435
Cellular Component	GO:0005737	cytoplasm	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:2155023\|PMID:11747369
Cellular Component	GO:0005737	cytoplasm	RGD:70884	Eif2ak3	ISS	Rat	RGD:1580654
Cellular Component	GO:0005783	endoplasmic reticulum	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:2677605\|PMID:14517290
Cellular Component	GO:0005783	endoplasmic reticulum	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:2136067\|PMID:11430819
Cellular Component	GO:0005789	endoplasmic reticulum membrane	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:1333015\|PMID:9930704
Cellular Component	GO:0005615	extracellular space	RGD:70884	Eif2ak3	ISS	Rat	RGD:1580654
Biological Process	GO:0008632	apoptotic program	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2136067\|PMID:11430819
Biological Process	GO:0030282	bone mineralization	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2179907\|PMID:11997520
Biological Process	GO:0019722	calcium-mediated signaling	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3614746\|PMID:16352659
Biological Process	GO:0006919	caspase activation	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:1858648\|PMID:10882126
Biological Process	GO:0001906	cell killing	WBGene00003970	pek-1	IGI	Worm	WB:WBPaper00005044\|PMID:11779465
Biological Process	GO:0002063	chondrocyte development	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2670283\|PMID:12865332
Biological Process	GO:0031018	endocrine pancreas development	Q9NZJ5	E2AK3_HUMAN	IMP	Human	PMID:12086964
Biological Process	GO:0031018	endocrine pancreas development	RGD:70884	Eif2ak3	ISS	Rat	RGD:1600115
Biological Process	GO:0007029	endoplasmic reticulum organization and biogenesis	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2136067\|PMID:11430819
Biological Process	GO:0006983	ER overload response	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:11907036
Biological Process	GO:0006983	ER overload response	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:10677345
Biological Process	GO:0006983	ER overload response	RGD:70884	Eif2ak3	ISS	Rat	RGD:1600115
Biological Process	GO:0030073	insulin secretion	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2136067\|PMID:11430819
Biological Process	GO:0030073	insulin secretion	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2179907\|PMID:11997520
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2670283\|PMID:12865332
Biological Process	GO:0002119	larval development (sensu Nematoda)	WBGene00003970	pek-1	IGI	Worm	WB:WBPaper00005044\|PMID:11779465
Biological Process	GO:0031642	negative regulation of myelination	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3583403\|PMID:15911877
Biological Process	GO:0017148	negative regulation of protein biosynthetic process	MGI:1341830	Eif2ak3	IGI	Mouse	MGI:MGI:3620306\|PMID:16176978
Biological Process	GO:0017148	negative regulation of protein biosynthetic process	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:1333015\|PMID:9930704
Biological Process	GO:0017148	negative regulation of protein biosynthetic process	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:1858648\|PMID:10882126
Biological Process	GO:0017148	negative regulation of protein biosynthetic process	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3620306\|PMID:16176978
Biological Process	GO:0032055	negative regulation of translation in response to stress	RGD:70884	Eif2ak3	IDA	Rat	RGD:70729\|PMID:9819435
Biological Process	GO:0031016	pancreas development	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2179907\|PMID:11997520
Biological Process	GO:0032092	positive regulation of protein binding	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3614746\|PMID:16352659
Biological Process	GO:0046777	protein amino acid autophosphorylation	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:11907036
Biological Process	GO:0046777	protein amino acid autophosphorylation	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:10026192
Biological Process	GO:0046777	protein amino acid autophosphorylation	Q9NZJ5	E2AK3_HUMAN	IMP	Human	PMID:12086964
Biological Process	GO:0046777	protein amino acid autophosphorylation	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:1333015\|PMID:9930704
Biological Process	GO:0046777	protein amino acid autophosphorylation	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3511630\|PMID:15542627
Biological Process	GO:0046777	protein amino acid autophosphorylation	RGD:70884	Eif2ak3	IMP	Rat	RGD:1581062\|PMID:15936177
Biological Process	GO:0046777	protein amino acid autophosphorylation	RGD:70884	Eif2ak3	ISS	Rat	RGD:1600115
Biological Process	GO:0046777	protein amino acid autophosphorylation	RGD:70884	Eif2ak3	IDA	Rat	RGD:70729\|PMID:9819435
Biological Process	GO:0006468	protein amino acid phosphorylation	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:2450792\|PMID:12388085
Biological Process	GO:0006468	protein amino acid phosphorylation	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3511630\|PMID:15542627
Biological Process	GO:0006468	protein amino acid phosphorylation	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:1333015\|PMID:9930704
Biological Process	GO:0006468	protein amino acid phosphorylation	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:1858648\|PMID:10882126
Biological Process	GO:0006468	protein amino acid phosphorylation	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2136067\|PMID:11430819
Biological Process	GO:0006468	protein amino acid phosphorylation	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3620306\|PMID:16176978
Biological Process	GO:0006468	protein amino acid phosphorylation	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2179907\|PMID:11997520
Biological Process	GO:0006468	protein amino acid phosphorylation	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:2677605\|PMID:14517290
Biological Process	GO:0006468	protein amino acid phosphorylation	RGD:70884	Eif2ak3	ISS	Rat	RGD:1580654
Biological Process	GO:0006468	protein amino acid phosphorylation	RGD:70884	Eif2ak3	IMP	Rat	RGD:1581062\|PMID:15936177
Biological Process	GO:0006468	protein amino acid phosphorylation	RGD:70884	Eif2ak3	IDA	Rat	RGD:70729\|PMID:9819435
Biological Process	GO:0051260	protein homooligomerization	Q9NZJ5	E2AK3_HUMAN	IMP	Human	PMID:11907036
Biological Process	GO:0051260	protein homooligomerization	RGD:70884	Eif2ak3	ISS	Rat	RGD:1600115
Biological Process	GO:0043558	regulation of translation initiation in response to stress	FBgn0037327	PEK	ISS	Fly	FB:FBrf0125266\|PMID:10677345
Biological Process	GO:0001501	skeletal development	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2179907\|PMID:11997520
Biological Process	GO:0006412	translation	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:2450792\|PMID:12388085
Biological Process	GO:0006412	translation	RGD:70884	Eif2ak3	ISS	Rat	RGD:1580654
Biological Process	GO:0030968	unfolded protein response	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:10677345
Biological Process	GO:0030968	unfolded protein response	Q9NZJ5	E2AK3_HUMAN	IDA	Human	PMID:11907036
Biological Process	GO:0030968	unfolded protein response	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:1333015\|PMID:9930704
Biological Process	GO:0030968	unfolded protein response	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:1858648\|PMID:10882126
Biological Process	GO:0030968	unfolded protein response	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:2136067\|PMID:11430819
Biological Process	GO:0030968	unfolded protein response	MGI:1341830	Eif2ak3	IDA	Mouse	MGI:MGI:2677605\|PMID:14517290
Biological Process	GO:0030968	unfolded protein response	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3511630\|PMID:15542627
Biological Process	GO:0030968	unfolded protein response	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3620306\|PMID:16176978
Biological Process	GO:0030968	unfolded protein response	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3583403\|PMID:15911877
Biological Process	GO:0030968	unfolded protein response	RGD:70884	Eif2ak3	ISS	Rat	RGD:1600115
Biological Process	GO:0006990	unfolded protein response, positive regulation of target gene transcription	WBGene00003970	pek-1	IEP	Worm	WB:WBPaper00026830\|PMID:16184190
Biological Process	GO:0006926	virus-infected cell apoptosis	MGI:1341830	Eif2ak3	IMP	Mouse	MGI:MGI:3511630\|PMID:15542627

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)