Compare GO annotations for HomoloGene:39748 orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, fly, worm, tair, rice, yeast, pombe, pfalc, zfin.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Fly from Flybase; Worm from Wormbase; Tair from TAIR; Rice from Gramene; Yeast from SGD; Pombe from S.pombe Genome Project; Pfalc from PlasmoDB; Zfin from Zfin.
Organisms with experimental annotations are indicated: IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IC, IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Tue Sep 18 15:47:31 2007.

Category	ID	Term	DB Object	DB Symbol	Evidence	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:12393916
Molecular Function	GO:0005516	calmodulin binding	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:10947957
Molecular Function	GO:0005516	calmodulin binding	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2447525\|PMID:12393916
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:10863092
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Q8N632	Q8N632_HUMAN	ISS	Human	UniProt:Q8N632
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Q96GK1	Q96GK1_HUMAN	ISS	Human	UniProt:Q96GK1
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	RGD:620048	Sphk1	ISS	Rat	RGD:1600115
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	FBgn0052484	Sk2	ISS	Fly	FB:FBrf0148886
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	FBgn0052484	Sk2	ISS	Fly	FB:FBrf0151669
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	FBgn0052484	Sk2	IDA	Fly	FB:FBrf0174774\|PMID:14722126
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	FBgn0052484	Sk2	ISS	Fly	FB:FBrf0174774\|PMID:14722126
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	S000005697	LCB4	IDA	Yeast	SGD_REF:S000052946\|PMID:9677363
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	SPAC4A8.07c	SPAC4A8.07c	ISS	Pombe	GOC:unpublished
Molecular Function	GO:0004143	diacylglycerol kinase activity	SPAC4A8.07c	SPAC4A8.07c	ISS	Pombe	GOC:unpublished
Molecular Function	GO:0003677	DNA binding	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:12393916
Molecular Function	GO:0003677	DNA binding	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2447525\|PMID:12393916
Molecular Function	GO:0000287	magnesium ion binding	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:10947957
Molecular Function	GO:0000287	magnesium ion binding	Q8N632	Q8N632_HUMAN	ISS	Human	UniProt:Q8N632
Molecular Function	GO:0000287	magnesium ion binding	Q96GK1	Q96GK1_HUMAN	ISS	Human	UniProt:Q96GK1
Molecular Function	GO:0000287	magnesium ion binding	RGD:620048	Sphk1	ISS	Rat	RGD:1600115
Molecular Function	GO:0005515	protein binding	Q8N632	Q8N632_HUMAN	IPI	Human	PMID:16316995
Molecular Function	GO:0008481	sphinganine kinase activity	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:15623571
Molecular Function	GO:0008481	sphinganine kinase activity	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:12393916
Molecular Function	GO:0008481	sphinganine kinase activity	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2447525\|PMID:12393916
Molecular Function	GO:0008481	sphinganine kinase activity	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2154458
Cellular Component	GO:0032541	cortical endoplasmic reticulum	S000005697	LCB4	IDA	Yeast	SGD_REF:S000123763\|PMID:17686782
Cellular Component	GO:0005737	cytoplasm	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:15623571
Cellular Component	GO:0005737	cytoplasm	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2154458
Cellular Component	GO:0005783	endoplasmic reticulum	S000005697	LCB4	IDA	Yeast	SGD_REF:S000072710\|PMID:12493772
Cellular Component	GO:0005783	endoplasmic reticulum	S000005697	LCB4	IDA	Yeast	SGD_REF:S000086678\|PMID:16141212
Cellular Component	GO:0005783	endoplasmic reticulum	SPAC4A8.07c	SPAC4A8.07c	ISS	Pombe	GOC:unpublished
Cellular Component	GO:0005794	Golgi apparatus	S000005697	LCB4	IDA	Yeast	SGD_REF:S000071822\|PMID:12459470
Cellular Component	GO:0005794	Golgi apparatus	SPAC4A8.07c	SPAC4A8.07c	ISS	Pombe	GOC:unpublished
Cellular Component	GO:0005624	membrane fraction	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2154458
Cellular Component	GO:0005624	membrane fraction	S000005697	LCB4	IDA	Yeast	SGD_REF:S000052946\|PMID:9677363
Cellular Component	GO:0005886	plasma membrane	S000005697	LCB4	IDA	Yeast	SGD_REF:S000086678\|PMID:16141212
Cellular Component	GO:0005625	soluble fraction	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:15623571
Cellular Component	GO:0005625	soluble fraction	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2154458
Cellular Component	GO:0005625	soluble fraction	S000005697	LCB4	IDA	Yeast	SGD_REF:S000052946\|PMID:9677363
Biological Process	GO:0001568	blood vessel development	MGI:1316649	Sphk1	IGI	Mouse	MGI:MGI:3610689\|PMID:16314531
Biological Process	GO:0001568	blood vessel development	RGD:620048	Sphk1	ISS	Rat	RGD:1580654
Biological Process	GO:0007420	brain development	MGI:1316649	Sphk1	IGI	Mouse	MGI:MGI:3610689\|PMID:16314531
Biological Process	GO:0007420	brain development	RGD:620048	Sphk1	ISS	Rat	RGD:1580654
Biological Process	GO:0019722	calcium-mediated signaling	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:10947957
Biological Process	GO:0019722	calcium-mediated signaling	S000005697	LCB4	IMP	Yeast	SGD_REF:S000060106\|PMID:11278643
Biological Process	GO:0019722	calcium-mediated signaling	SPAC4A8.07c	SPAC4A8.07c	ISS	Pombe	GOC:unpublished
Biological Process	GO:0007629	flight behavior	FBgn0052484	Sk2	IMP	Fly	FB:FBrf0174774\|PMID:14722126
Biological Process	GO:0043066	negative regulation of apoptosis	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2154458
Biological Process	GO:0018991	oviposition	FBgn0052484	Sk2	IMP	Fly	FB:FBrf0174774\|PMID:14722126
Biological Process	GO:0016310	phosphorylation	FBgn0052484	Sk2	ISS	Fly	FB:FBrf0148886
Biological Process	GO:0016310	phosphorylation	FBgn0052484	Sk2	IDA	Fly	FB:FBrf0174774\|PMID:14722126
Biological Process	GO:0045766	positive regulation of angiogenesis	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:12441135
Biological Process	GO:0030307	positive regulation of cell growth	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:12441135
Biological Process	GO:0030335	positive regulation of cell migration	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:12441135
Biological Process	GO:0008284	positive regulation of cell proliferation	MGI:1316649	Sphk1	IGI	Mouse	MGI:MGI:3610689\|PMID:16314531
Biological Process	GO:0008284	positive regulation of cell proliferation	RGD:620048	Sphk1	ISS	Rat	RGD:1580654
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:15623571
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	MGI:1316649	Sphk1	ISS	Mouse	MGI:MGI:2154458
Biological Process	GO:0045931	positive regulation of progression through mitotic cell cycle	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:12441135
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Q9NYA1	SPHK1_HUMAN	IDA	Human	PMID:12847068
Biological Process	GO:0007205	protein kinase C activation	SPAC4A8.07c	SPAC4A8.07c	ISS	Pombe	GOC:unpublished
Biological Process	GO:0046519	sphingoid metabolic process	SPAC4A8.07c	SPAC4A8.07c	ISS	Pombe	GOC:unpublished
Biological Process	GO:0006665	sphingolipid metabolic process	FBgn0052484	Sk2	IDA	Fly	FB:FBrf0174774\|PMID:14722126
Biological Process	GO:0006665	sphingolipid metabolic process	S000005697	LCB4	IDA	Yeast	SGD_REF:S000052946\|PMID:9677363
Biological Process	GO:0006670	sphingosine metabolic process	FBgn0052484	Sk2	ISS	Fly	FB:FBrf0174774\|PMID:14722126

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)