Compare GO annotations for HomoloGene:4451 orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, fly, worm, tair, rice, yeast, pombe, pfalc, zfin.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Fly from Flybase; Worm from Wormbase; Tair from TAIR; Rice from Gramene; Yeast from SGD; Pombe from S.pombe Genome Project; Pfalc from PlasmoDB; Zfin from Zfin.
Organisms with experimental annotations are indicated: IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IC, IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Tue Sep 18 15:47:31 2007.

Category	ID	Term	DB Object	DB Symbol	Evidence	Organism	Reference
Molecular Function	GO:0030552	cAMP binding	RGD:621886	Rapgef4	IDA	Rat	RGD:632397\|PMID:9856955
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Molecular Function	GO:0017132	cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity	FBgn0085421	Epac	ISS	Fly	FB:FBrf0105495
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2151174\|PMID:11056535
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RGD:621886	Rapgef4	IDA	Rat	RGD:632397\|PMID:9856955
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RGD:621886	Rapgef4	ISS	Rat	RGD:1580655
Molecular Function	GO:0005515	protein binding	Q8WZA2	RPGF4_HUMAN	IPI	Human	PMID:11438518
Molecular Function	GO:0005515	protein binding	MGI:1917723	Rapgef4	IPI	Mouse	MGI:MGI:3694182\|PMID:16316996
Molecular Function	GO:0005515	protein binding	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Molecular Function	GO:0005515	protein binding	RGD:621886	Rapgef4	ISS	Rat	RGD:1580655
Molecular Function	GO:0017034	Rap guanyl-nucleotide exchange factor activity	FBgn0085421	Epac	ISS	Fly	FB:FBrf0105495
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Cellular Component	GO:0005829	cytosol	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2151174\|PMID:11056535
Cellular Component	GO:0005829	cytosol	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Cellular Component	GO:0005624	membrane fraction	RGD:621886	Rapgef4	ISS	Rat	RGD:1580655
Biological Process	GO:0017156	calcium ion-dependent exocytosis	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2151174\|PMID:11056535
Biological Process	GO:0017156	calcium ion-dependent exocytosis	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Biological Process	GO:0019933	cAMP-mediated signaling	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2151174\|PMID:11056535
Biological Process	GO:0019933	cAMP-mediated signaling	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2154654\|PMID:11598134
Biological Process	GO:0019933	cAMP-mediated signaling	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2447935\|PMID:12401793
Biological Process	GO:0019933	cAMP-mediated signaling	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Biological Process	GO:0007186	G-protein coupled receptor protein signaling pathway	RGD:621886	Rapgef4	ISS	Rat	RGD:1580655
Biological Process	GO:0030073	insulin secretion	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2154654\|PMID:11598134
Biological Process	GO:0030073	insulin secretion	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2447935\|PMID:12401793
Biological Process	GO:0030073	insulin secretion	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Biological Process	GO:0007242	intracellular signaling cascade	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Biological Process	GO:0006468	protein amino acid phosphorylation	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Biological Process	GO:0017157	regulation of exocytosis	MGI:1917723	Rapgef4	IDA	Mouse	MGI:MGI:2447935\|PMID:12401793
Biological Process	GO:0017157	regulation of exocytosis	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654
Biological Process	GO:0007165	signal transduction	RGD:621886	Rapgef4	IDA	Rat	RGD:632397\|PMID:9856955
Biological Process	GO:0007264	small GTPase mediated signal transduction	RGD:621886	Rapgef4	ISS	Rat	RGD:1580654

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)