Compare GO annotations for HomoloGene:462 orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, fly, worm, tair, rice, yeast, pombe, pfalc, zfin.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Fly from Flybase; Worm from Wormbase; Tair from TAIR; Rice from Gramene; Yeast from SGD; Pombe from S.pombe Genome Project; Pfalc from PlasmoDB; Zfin from Zfin.
Organisms with experimental annotations are indicated: IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IC, IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Tue Sep 18 15:47:31 2007.

Category	ID	Term	DB Object	DB Symbol	Evidence	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	RGD:3908	Tsc2	IDA	Rat	RGD:1580520\|PMID:12869586
Molecular Function	GO:0030695	GTPase regulator activity	RGD:3908	Tsc2	IMP	Rat	RGD:1601406\|PMID:15611338
Molecular Function	GO:0019900	kinase binding	FBgn0005198	gig	IPI	Fly	FB:FBrf0152245\|PMID:12172555
Molecular Function	GO:0005515	protein binding	P49815	TSC2_HUMAN	IPI	Human	PMID:10585443
Molecular Function	GO:0005515	protein binding	P49815	TSC2_HUMAN	IPI	Human	PMID:12364343
Molecular Function	GO:0005515	protein binding	P49815	TSC2_HUMAN	IPI	Human	PMID:9580671
Molecular Function	GO:0005515	protein binding	MGI:102548	Tsc2	IPI	Mouse	MGI:MGI:2155582\|PMID:11741832
Molecular Function	GO:0005515	protein binding	RGD:3908	Tsc2	IPI	Rat	RGD:1304444\|PMID:14559897
Molecular Function	GO:0005515	protein binding	RGD:3908	Tsc2	IPI	Rat	RGD:1601351\|PMID:17379185
Molecular Function	GO:0005515	protein binding	RGD:3908	Tsc2	IMP	Rat	RGD:1601406\|PMID:15611338
Molecular Function	GO:0046982	protein heterodimerization activity	RGD:3908	Tsc2	IPI	Rat	RGD:1580491\|PMID:15093748
Molecular Function	GO:0042803	protein homodimerization activity	P49815	TSC2_HUMAN	IPI	Human	PMID:10585443
Molecular Function	GO:0005102	receptor binding	MGI:102548	Tsc2	ISS	Mouse	MGI:MGI:2154458
Cellular Component	GO:0016599	caveolar membrane	RGD:3908	Tsc2	IDA	Rat	RGD:1580491\|PMID:15093748
Cellular Component	GO:0005737	cytoplasm	P49815	TSC2_HUMAN	IDA	Human	PMID:9580671
Cellular Component	GO:0005737	cytoplasm	MGI:102548	Tsc2	IDA	Mouse	MGI:MGI:2155582\|PMID:11741832
Cellular Component	GO:0044430	cytoskeletal part	RGD:3908	Tsc2	IDA	Rat	RGD:1601407\|PMID:12147258
Cellular Component	GO:0005829	cytosol	P49815	TSC2_HUMAN	IDA	Human	PMID:10585443
Cellular Component	GO:0005829	cytosol	RGD:3908	Tsc2	IDA	Rat	RGD:1601407\|PMID:12147258
Cellular Component	GO:0030426	growth cone	RGD:3908	Tsc2	IDA	Rat	RGD:1304444\|PMID:14559897
Cellular Component	GO:0045121	lipid raft	RGD:3908	Tsc2	IDA	Rat	RGD:1580491\|PMID:15093748
Cellular Component	GO:0005792	microsome	RGD:3908	Tsc2	IDA	Rat	RGD:1580491\|PMID:15093748
Cellular Component	GO:0005792	microsome	RGD:3908	Tsc2	IDA	Rat	RGD:1601407\|PMID:12147258
Cellular Component	GO:0043005	neuron projection	RGD:3908	Tsc2	IDA	Rat	RGD:1304444\|PMID:14559897
Cellular Component	GO:0005634	nucleus	MGI:102548	Tsc2	ISS	Mouse	MGI:MGI:2154458
Cellular Component	GO:0048471	perinuclear region of cytoplasm	RGD:3908	Tsc2	IDA	Rat	RGD:1304444\|PMID:14559897
Cellular Component	GO:0043234	protein complex	RGD:3908	Tsc2	IMP	Rat	RGD:1601406\|PMID:15611338
Cellular Component	GO:0043234	protein complex	RGD:3908	Tsc2	IDA	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0006953	acute-phase response	RGD:3908	Tsc2	IMP	Rat	RGD:625610\|PMID:7651821
Biological Process	GO:0030030	cell projection organization and biogenesis	MGI:102548	Tsc2	ISS	Mouse	MGI:MGI:3610880\|PMID:16286931
Biological Process	GO:0008340	determination of adult life span	FBgn0005198	gig	IMP	Fly	FB:FBrf0179269\|PMID:15186745
Biological Process	GO:0045184	establishment of protein localization	RGD:3908	Tsc2	IMP	Rat	RGD:1580491\|PMID:15093748
Biological Process	GO:0007507	heart development	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:1333508\|PMID:10096549
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:102548	Tsc2	IGI	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0030308	negative regulation of cell growth	FBgn0005198	gig	IGI	Fly	FB:FBrf0135684\|PMID:11348591
Biological Process	GO:0030308	negative regulation of cell growth	FBgn0005198	gig	IMP	Fly	FB:FBrf0135684\|PMID:11348591
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:1333508\|PMID:10096549
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	Tsc2	IGI	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:1345025\|PMID:10491404
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:1858852\|PMID:10827137
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	Tsc2	IGI	Mouse	MGI:MGI:3586938\|PMID:16027168
Biological Process	GO:0008285	negative regulation of cell proliferation	RGD:3908	Tsc2	IMP	Rat	RGD:625610\|PMID:7651821
Biological Process	GO:0008285	negative regulation of cell proliferation	FBgn0005198	gig	IGI	Fly	FB:FBrf0135684\|PMID:11348591
Biological Process	GO:0045792	negative regulation of cell size	MGI:102548	Tsc2	ISS	Mouse	MGI:MGI:3610880\|PMID:16286931
Biological Process	GO:0045792	negative regulation of cell size	FBgn0005198	gig	IGI	Fly	FB:FBrf0136941\|PMID:11390358
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	RGD:3908	Tsc2	IDA	Rat	RGD:1580517\|PMID:14612383
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	FBgn0005198	gig	IGI	Fly	FB:FBrf0136941\|PMID:11390358
Biological Process	GO:0043407	negative regulation of MAPK activity	RGD:3908	Tsc2	IMP	Rat	RGD:1580517\|PMID:14612383
Biological Process	GO:0046621	negative regulation of organ size	FBgn0005198	gig	IGI	Fly	FB:FBrf0136941\|PMID:11390358
Biological Process	GO:0014067	negative regulation of phosphoinositide 3-kinase cascade	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0006469	negative regulation of protein kinase activity	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0051898	negative regulation of protein kinase B signaling cascade	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0051898	negative regulation of protein kinase B signaling cascade	MGI:102548	Tsc2	IGI	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0032007	negative regulation of TOR signaling pathway	RGD:3908	Tsc2	IDA	Rat	RGD:1580520\|PMID:12869586
Biological Process	GO:0030178	negative regulation of Wnt receptor signaling pathway	RGD:3908	Tsc2	IDA	Rat	RGD:1304267\|PMID:12511557
Biological Process	GO:0001843	neural tube closure	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:1333508\|PMID:10096549
Biological Process	GO:0014065	phosphoinositide 3-kinase cascade	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0050918	positive chemotaxis	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0051291	protein heterooligomerization	RGD:3908	Tsc2	IDA	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0051291	protein heterooligomerization	RGD:3908	Tsc2	IMP	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0051260	protein homooligomerization	RGD:3908	Tsc2	IDA	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0051260	protein homooligomerization	RGD:3908	Tsc2	IMP	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0006606	protein import into nucleus	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:1858852\|PMID:10827137
Biological Process	GO:0043491	protein kinase B signaling cascade	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling cascade	MGI:102548	Tsc2	IGI	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0008104	protein localization	MGI:102548	Tsc2	IDA	Mouse	MGI:MGI:2155582\|PMID:11741832
Biological Process	GO:0032956	regulation of actin cytoskeleton organization and biogenesis	RGD:3908	Tsc2	IMP	Rat	RGD:1601406\|PMID:15611338
Biological Process	GO:0030100	regulation of endocytosis	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:1858852\|PMID:10827137
Biological Process	GO:0051893	regulation of focal adhesion formation	RGD:3908	Tsc2	IMP	Rat	RGD:1601406\|PMID:15611338
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	MGI:102548	Tsc2	IMP	Mouse	MGI:MGI:2429349\|PMID:12403809
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	RGD:3908	Tsc2	ISS	Rat	RGD:1580654
Biological Process	GO:0000074	regulation of progression through cell cycle	RGD:3908	Tsc2	IMP	Rat	RGD:625610\|PMID:7651821
Biological Process	GO:0000074	regulation of progression through cell cycle	FBgn0005198	gig	IMP	Fly	FB:FBrf0107789\|PMID:10052455
Biological Process	GO:0000074	regulation of progression through cell cycle	FBgn0005198	gig	IMP	Fly	FB:FBrf0135684\|PMID:11348591
Biological Process	GO:0051492	regulation of stress fiber formation	RGD:3908	Tsc2	IMP	Rat	RGD:1601406\|PMID:15611338
Biological Process	GO:0007584	response to nutrient	FBgn0005198	gig	IMP	Fly	FB:FBrf0152245\|PMID:12172555
Biological Process	GO:0007165	signal transduction	RGD:3908	Tsc2	IDA	Rat	RGD:625501\|PMID:12045200
Biological Process	GO:0007165	signal transduction	FBgn0005198	gig	IGI	Fly	FB:FBrf0152245\|PMID:12172555

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)