MGI MouseCyc GO annotations for PWY-5004

MGI MouseCyc GO annotations for PWY-5004: superpathway of citrulline metabolism

Roles of genes might be detected in a summary/comparison table of high level GO categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";
Black arrows indicate "regulates";
Green arrows indicate "positively_regulates";
Red arrows indicate "negatively_regulates"

Compare annotations to GO categories for PWY-5004.

Entry indicates that gene is in this pathway.
Colored entries indicate GO annotation.

Category	ID	Term	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Molecular Function	GO:0005488	binding	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Molecular Function	GO:0003824	catalytic activity	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Molecular Function	GO:0009055	electron carrier activity	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Cellular Component	GO:0005623	cell	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Cellular Component	GO:0044464	cell part	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Cellular Component	GO:0031975	envelope	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Cellular Component	GO:0032991	macromolecular complex	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Cellular Component	GO:0043226	organelle	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Cellular Component	GO:0044422	organelle part	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Cellular Component	GO:0045202	synapse	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0065007	biological regulation	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0009987	cellular process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0032502	developmental process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0051234	establishment of localization	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0051179	localization	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0008152	metabolic process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0051704	multi-organism process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0032501	multicellular organismal process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0048519	negative regulation of biological process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0048518	positive regulation of biological process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0050789	regulation of biological process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0000003	reproduction	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0022414	reproductive process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0050896	response to stimulus	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2
Biological Process	GO:0048511	rhythmic process	Aldh18a1	Arg1	Arg2	Asl	Ass1	Cps1	Gls	Gls2	Nos1	Nos1ap	Nos2	Nos3	Nosip	Oat	Otc	Prodh	Prodh2

Full set of annotations for PWY-5004

Category	ID	Term	Mouse gene	Evidence	Color Key
Molecular Function	GO:0016597	amino acid binding	Otc	IEA	color key
Molecular Function	GO:0004053	arginase activity	Arg2	ISO	color key
Molecular Function	GO:0004053	arginase activity	Arg1	IDA	color key
Molecular Function	GO:0034618	arginine binding	Nos2	IDA	color key
Molecular Function	GO:0004056	argininosuccinate lyase activity	Asl	IEA	color key
Molecular Function	GO:0004055	argininosuccinate synthase activity	Ass1	IEA	color key
Molecular Function	GO:0005524	ATP binding	Ass1	IEA	color key
Molecular Function	GO:0005524	ATP binding	Cps1	IEA	color key
Molecular Function	GO:0005509	calcium ion binding	Nos3	IEA	color key
Molecular Function	GO:0005516	calmodulin binding	Nos1	IEA	color key
Molecular Function	GO:0005516	calmodulin binding	Nos2	TAS	color key
Molecular Function	GO:0005516	calmodulin binding	Nos3	IEA	color key
Molecular Function	GO:0004087	carbamoyl-phosphate synthase (ammonia) activity	Cps1	IEA	color key
Molecular Function	GO:0004086	carbamoyl-phosphate synthase activity	Cps1	IMP	color key
Molecular Function	GO:0016743	carboxyl- or carbamoyltransferase activity	Otc	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Aldh18a1	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Asl	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Cps1	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Oat	IEA	color key
Molecular Function	GO:0009055	electron carrier activity	Nos1	IEA	color key
Molecular Function	GO:0009055	electron carrier activity	Nos2	IEA	color key
Molecular Function	GO:0009055	electron carrier activity	Nos3	IEA	color key
Molecular Function	GO:0050660	FAD binding	Nos1	IEA	color key
Molecular Function	GO:0050660	FAD binding	Nos2	IEA	color key
Molecular Function	GO:0050660	FAD binding	Nos3	IEA	color key
Molecular Function	GO:0010181	FMN binding	Nos1	IEA	color key
Molecular Function	GO:0010181	FMN binding	Nos2	IEA	color key
Molecular Function	GO:0010181	FMN binding	Nos3	IEA	color key
Molecular Function	GO:0004349	glutamate 5-kinase activity	Aldh18a1	IDA	color key
Molecular Function	GO:0004349	glutamate 5-kinase activity	Aldh18a1	IGI	color key
Molecular Function	GO:0004350	glutamate-5-semialdehyde dehydrogenase activity	Aldh18a1	IEA	color key
Molecular Function	GO:0004359	glutaminase activity	Gls2	IEA	color key
Molecular Function	GO:0004359	glutaminase activity	Gls	IMP	color key
Molecular Function	GO:0020037	heme binding	Nos1	IEA	color key
Molecular Function	GO:0020037	heme binding	Nos2	IEA	color key
Molecular Function	GO:0020037	heme binding	Nos3	IEA	color key
Molecular Function	GO:0016787	hydrolase activity	Arg2	IEA	color key
Molecular Function	GO:0016787	hydrolase activity	Gls2	IEA	color key
Molecular Function	GO:0016787	hydrolase activity	Arg1	IEA	color key
Molecular Function	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	Arg2	IEA	color key
Molecular Function	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	Arg1	IEA	color key
Molecular Function	GO:0005506	iron ion binding	Nos1	IEA	color key
Molecular Function	GO:0005506	iron ion binding	Nos2	IEA	color key
Molecular Function	GO:0005506	iron ion binding	Nos3	IEA	color key
Molecular Function	GO:0016301	kinase activity	Aldh18a1	IEA	color key
Molecular Function	GO:0016874	ligase activity	Ass1	IEA	color key
Molecular Function	GO:0016874	ligase activity	Cps1	IEA	color key
Molecular Function	GO:0016829	lyase activity	Asl	IEA	color key
Molecular Function	GO:0030145	manganese ion binding	Arg2	IEA	color key
Molecular Function	GO:0030145	manganese ion binding	Arg1	IEA	color key
Molecular Function	GO:0046872	metal ion binding	Arg2	IEA	color key
Molecular Function	GO:0046872	metal ion binding	Arg1	IEA	color key
Molecular Function	GO:0046872	metal ion binding	Nos1	IEA	color key
Molecular Function	GO:0046872	metal ion binding	Nos2	IEA	color key
Molecular Function	GO:0046872	metal ion binding	Nos3	IEA	color key
Molecular Function	GO:0050661	NADP binding	Nos1	IEA	color key
Molecular Function	GO:0050661	NADP binding	Nos2	IEA	color key
Molecular Function	GO:0050661	NADP binding	Nos3	IEA	color key
Molecular Function	GO:0004517	nitric-oxide synthase activity	Nos1	IEA	color key
Molecular Function	GO:0004517	nitric-oxide synthase activity	Nos2	IEA	color key
Molecular Function	GO:0004517	nitric-oxide synthase activity	Nos3	IMP	color key
Molecular Function	GO:0050998	nitric-oxide synthase binding	Nos1ap	ISO	color key
Molecular Function	GO:0000166	nucleotide binding	Ass1	IEA	color key
Molecular Function	GO:0000166	nucleotide binding	Cps1	IEA	color key
Molecular Function	GO:0004585	ornithine carbamoyltransferase activity	Otc	IEA	color key
Molecular Function	GO:0004587	ornithine-oxo-acid transaminase activity	Oat	IEA	color key
Molecular Function	GO:0016491	oxidoreductase activity	Aldh18a1	IEA	color key
Molecular Function	GO:0016491	oxidoreductase activity	Prodh2	IEA	color key
Molecular Function	GO:0016491	oxidoreductase activity	Nos1	IEA	color key
Molecular Function	GO:0016491	oxidoreductase activity	Nos2	IEA	color key
Molecular Function	GO:0016491	oxidoreductase activity	Nos3	IEA	color key
Molecular Function	GO:0016491	oxidoreductase activity	Prodh	IEA	color key
Molecular Function	GO:0030165	PDZ domain binding	Nos1ap	ISO	color key
Molecular Function	GO:0004657	proline dehydrogenase activity	Prodh2	IEA	color key
Molecular Function	GO:0004657	proline dehydrogenase activity	Prodh	ISS	color key
Molecular Function	GO:0005515	protein binding	Arg2	ISO	color key
Molecular Function	GO:0005515	protein binding	Nos1	ISO	color key
Molecular Function	GO:0005515	protein binding	Nos2	IPI	color key
Molecular Function	GO:0042803	protein homodimerization activity	Nos2	IDA	color key
Molecular Function	GO:0030170	pyridoxal phosphate binding	Oat	IEA	color key
Molecular Function	GO:0034617	tetrahydrobiopterin binding	Nos2	IDA	color key
Molecular Function	GO:0008483	transaminase activity	Oat	IEA	color key
Molecular Function	GO:0016740	transferase activity	Aldh18a1	IEA	color key
Molecular Function	GO:0016740	transferase activity	Oat	IEA	color key
Molecular Function	GO:0016740	transferase activity	Otc	IEA	color key
Molecular Function	GO:0004842	ubiquitin-protein ligase activity	Nosip	IEA	color key
Molecular Function	GO:0008270	zinc ion binding	Nos2	IEA	color key
Molecular Function	GO:0008270	zinc ion binding	Nos3	IEA	color key
Cellular Component	GO:0042995	cell projection	Nos1	IEA	color key
Cellular Component	GO:0030863	cortical cytoskeleton	Nos2	IDA	color key
Cellular Component	GO:0005737	cytoplasm	Aldh18a1	IEA	color key
Cellular Component	GO:0005737	cytoplasm	Nosip	IEA	color key
Cellular Component	GO:0005737	cytoplasm	Arg1	IEA	color key
Cellular Component	GO:0005737	cytoplasm	Nos2	IDA	color key
Cellular Component	GO:0005737	cytoplasm	Nos3	IEA	color key
Cellular Component	GO:0005856	cytoskeleton	Nos1	IDA	color key
Cellular Component	GO:0005856	cytoskeleton	Nos3	IEA	color key
Cellular Component	GO:0005829	cytosol	Nos2	TAS	color key
Cellular Component	GO:0005794	Golgi apparatus	Nos3	IEA	color key
Cellular Component	GO:0005622	intracellular	Cps1	IDA	color key
Cellular Component	GO:0016020	membrane	Aldh18a1	IEA	color key
Cellular Component	GO:0016020	membrane	Nos1	IEA	color key
Cellular Component	GO:0016020	membrane	Nos3	IEA	color key
Cellular Component	GO:0005743	mitochondrial inner membrane	Aldh18a1	IEA	color key
Cellular Component	GO:0005743	mitochondrial inner membrane	Prodh2	IDA	color key
Cellular Component	GO:0005743	mitochondrial inner membrane	Otc	IDA	color key
Cellular Component	GO:0005743	mitochondrial inner membrane	Prodh	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Arg2	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Arg2	ISO	color key
Cellular Component	GO:0005739	mitochondrion	Aldh18a1	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Gls2	IEA	color key
Cellular Component	GO:0005739	mitochondrion	Ass1	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Cps1	IEA	color key
Cellular Component	GO:0005739	mitochondrion	Nos1	ISO	color key
Cellular Component	GO:0005739	mitochondrion	Oat	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Otc	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Prodh	IEA	color key
Cellular Component	GO:0005634	nucleus	Nosip	IEA	color key
Cellular Component	GO:0009348	ornithine carbamoyltransferase complex	Otc	IEA	color key
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Nos2	IDA	color key
Cellular Component	GO:0005886	plasma membrane	Nos1	IEA	color key
Cellular Component	GO:0005886	plasma membrane	Nos3	IEA	color key
Cellular Component	GO:0042383	sarcolemma	Nos1	IDA	color key
Cellular Component	GO:0045202	synapse	Nos1	IDA	color key
Cellular Component	GO:0000151	ubiquitin ligase complex	Nosip	IEA	color key
Biological Process	GO:0008652	amino acid biosynthetic process	Aldh18a1	TAS	color key
Biological Process	GO:0008652	amino acid biosynthetic process	Asl	IEA	color key
Biological Process	GO:0008652	amino acid biosynthetic process	Ass1	IEA	color key
Biological Process	GO:0008652	amino acid biosynthetic process	Otc	IEA	color key
Biological Process	GO:0006520	amino acid metabolic process	Asl	IMP	color key
Biological Process	GO:0006520	amino acid metabolic process	Otc	IEA	color key
Biological Process	GO:0019676	ammonia assimilation cycle	Asl	IMP	color key
Biological Process	GO:0001525	angiogenesis	Nos3	IMP	color key
Biological Process	GO:0006526	arginine biosynthetic process	Asl	IEA	color key
Biological Process	GO:0006526	arginine biosynthetic process	Ass1	IEA	color key
Biological Process	GO:0006526	arginine biosynthetic process	Otc	IEA	color key
Biological Process	GO:0042450	arginine biosynthetic process via ornithine	Asl	IEA	color key
Biological Process	GO:0006525	arginine metabolic process	Arg2	IEA	color key
Biological Process	GO:0006525	arginine metabolic process	Arg1	IEA	color key
Biological Process	GO:0007610	behavior	Gls	IMP	color key
Biological Process	GO:0001974	blood vessel remodeling	Nos3	IMP	color key
Biological Process	GO:0042742	defense response to bacterium	Nos2	IMP	color key
Biological Process	GO:0042738	exogenous drug catabolic process	Nos1	IMP	color key
Biological Process	GO:0006537	glutamate biosynthetic process	Prodh2	IEA	color key
Biological Process	GO:0006537	glutamate biosynthetic process	Prodh	IEA	color key
Biological Process	GO:0006543	glutamine catabolic process	Gls	IMP	color key
Biological Process	GO:0006541	glutamine metabolic process	Gls2	IEA	color key
Biological Process	GO:0006541	glutamine metabolic process	Cps1	IEA	color key
Biological Process	GO:0006954	inflammatory response	Nos2	TAS	color key
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Nos3	IMP	color key
Biological Process	GO:0007626	locomotory behavior	Asl	IMP	color key
Biological Process	GO:0030324	lung development	Nos3	IMP	color key
Biological Process	GO:0008152	metabolic process	Aldh18a1	IEA	color key
Biological Process	GO:0008152	metabolic process	Cps1	IEA	color key
Biological Process	GO:0051926	negative regulation of calcium ion transport	Nos1	IMP	color key
Biological Process	GO:0051926	negative regulation of calcium ion transport	Nos3	IMP	color key
Biological Process	GO:0051346	negative regulation of hydrolase activity	Nos1	IMP	color key
Biological Process	GO:0051346	negative regulation of hydrolase activity	Nos3	IMP	color key
Biological Process	GO:0014740	negative regulation of muscle hyperplasia	Nos3	IMP	color key
Biological Process	GO:0043267	negative regulation of potassium ion transport	Nos1	IMP	color key
Biological Process	GO:0043267	negative regulation of potassium ion transport	Nos3	IMP	color key
Biological Process	GO:0006809	nitric oxide biosynthetic process	Nos1	IEA	color key
Biological Process	GO:0006809	nitric oxide biosynthetic process	Nos2	IDA	color key
Biological Process	GO:0006809	nitric oxide biosynthetic process	Nos3	IMP	color key
Biological Process	GO:0006807	nitrogen compound metabolic process	Cps1	IEA	color key
Biological Process	GO:0001542	ovulation from ovarian follicle	Nos3	IMP	color key
Biological Process	GO:0055114	oxidation reduction	Aldh18a1	IEA	color key
Biological Process	GO:0055114	oxidation reduction	Prodh2	IEA	color key
Biological Process	GO:0055114	oxidation reduction	Nos1	IEA	color key
Biological Process	GO:0055114	oxidation reduction	Nos2	IEA	color key
Biological Process	GO:0055114	oxidation reduction	Nos3	IEA	color key
Biological Process	GO:0055114	oxidation reduction	Prodh	IEA	color key
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation	Nos1	IDA	color key
Biological Process	GO:0045766	positive regulation of angiogenesis	Nos3	IMP	color key
Biological Process	GO:0009791	post-embryonic development	Asl	IMP	color key
Biological Process	GO:0006561	proline biosynthetic process	Aldh18a1	IEA	color key
Biological Process	GO:0006562	proline catabolic process	Prodh2	IEA	color key
Biological Process	GO:0006562	proline catabolic process	Prodh	IEA	color key
Biological Process	GO:0006560	proline metabolic process	Prodh2	IEA	color key
Biological Process	GO:0006560	proline metabolic process	Prodh	IEA	color key
Biological Process	GO:0016567	protein ubiquitination	Nosip	IEA	color key
Biological Process	GO:0050880	regulation of blood vessel size	Nos3	IMP	color key
Biological Process	GO:0042127	regulation of cell proliferation	Nos2	IGI	color key
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by neurological process	Gls	IMP	color key
Biological Process	GO:0002028	regulation of sodium ion transport	Nos1	IMP	color key
Biological Process	GO:0002028	regulation of sodium ion transport	Nos3	IMP	color key
Biological Process	GO:0001666	response to hypoxia	Nos2	IDA	color key
Biological Process	GO:0014806	smooth muscle hyperplasia	Nos3	IMP	color key
Biological Process	GO:0006941	striated muscle contraction	Arg2	IMP	color key
Biological Process	GO:0006941	striated muscle contraction	Nos1	IMP	color key
Biological Process	GO:0006801	superoxide metabolic process	Nos2	IMP	color key
Biological Process	GO:0007268	synaptic transmission	Gls	IMP	color key
Biological Process	GO:0000050	urea cycle	Arg2	IEA	color key
Biological Process	GO:0000050	urea cycle	Arg1	IEA	color key
Biological Process	GO:0000050	urea cycle	Asl	IEA	color key
Biological Process	GO:0000050	urea cycle	Ass1	IEA	color key
Biological Process	GO:0000050	urea cycle	Cps1	IEA	color key
Biological Process	GO:0000050	urea cycle	Otc	IEA	color key