MGI MouseCyc GO annotations for PWY-922

MGI MouseCyc GO annotations for PWY-922: mevalonate pathway

Roles of genes might be detected in a summary/comparison table of high level GO categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";
Black arrows indicate "regulates";
Green arrows indicate "positively_regulates";
Red arrows indicate "negatively_regulates"

Compare annotations to GO categories for PWY-922.

Entry indicates that gene is in this pathway.
Colored entries indicate GO annotation.

Category	ID	Term	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Molecular Function	GO:0005488	binding	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Molecular Function	GO:0003824	catalytic activity	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Cellular Component	GO:0005623	cell	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Cellular Component	GO:0044464	cell part	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Cellular Component	GO:0031975	envelope	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Cellular Component	GO:0043226	organelle	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Cellular Component	GO:0044422	organelle part	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Biological Process	GO:0065007	biological regulation	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Biological Process	GO:0009987	cellular process	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Biological Process	GO:0032502	developmental process	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Biological Process	GO:0008152	metabolic process	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Biological Process	GO:0032501	multicellular organismal process	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk
Biological Process	GO:0050896	response to stimulus	Acat1	Acat2	Hmgcr	Hmgcs1	Hmgcs2	Idi1	Idi2	Mvd	Mvk	Nudt12	Pmvk

Full set of annotations for PWY-922

Category	ID	Term	Mouse gene	Evidence	Color Key
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	Acat1	IDA	color key
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	Acat2	IEA	color key
Molecular Function	GO:0008415	acyltransferase activity	Acat1	IEA	color key
Molecular Function	GO:0008415	acyltransferase activity	Acat2	IEA	color key
Molecular Function	GO:0005524	ATP binding	Mvk	IEA	color key
Molecular Function	GO:0005524	ATP binding	Mvd	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Acat1	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Acat2	IEA	color key
Molecular Function	GO:0050662	coenzyme binding	Hmgcr	IEA	color key
Molecular Function	GO:0004163	diphosphomevalonate decarboxylase activity	Mvd	IEA	color key
Molecular Function	GO:0016787	hydrolase activity	Nudt12	IEA	color key
Molecular Function	GO:0016787	hydrolase activity	Idi1	IEA	color key
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA	color key
Molecular Function	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	Hmgcs2	IEA	color key
Molecular Function	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	Hmgcs1	IEA	color key
Molecular Function	GO:0016853	isomerase activity	Idi1	IEA	color key
Molecular Function	GO:0016853	isomerase activity	Idi2	IEA	color key
Molecular Function	GO:0004452	isopentenyl-diphosphate delta-isomerase activity	Idi1	IEA	color key
Molecular Function	GO:0016301	kinase activity	Mvk	IEA	color key
Molecular Function	GO:0016301	kinase activity	Pmvk	IEA	color key
Molecular Function	GO:0016301	kinase activity	Mvd	IEA	color key
Molecular Function	GO:0016829	lyase activity	Mvd	IEA	color key
Molecular Function	GO:0000287	magnesium ion binding	Nudt12	IEA	color key
Molecular Function	GO:0000287	magnesium ion binding	Idi1	IEA	color key
Molecular Function	GO:0030145	manganese ion binding	Nudt12	IEA	color key
Molecular Function	GO:0046872	metal ion binding	Nudt12	IEA	color key
Molecular Function	GO:0046872	metal ion binding	Idi1	IEA	color key
Molecular Function	GO:0046872	metal ion binding	Acat1	IEA	color key
Molecular Function	GO:0004496	mevalonate kinase activity	Mvk	IDA	color key
Molecular Function	GO:0000210	NAD+ diphosphatase activity	Nudt12	IEA	color key
Molecular Function	GO:0050661	NADP binding	Hmgcr	IEA	color key
Molecular Function	GO:0000166	nucleotide binding	Mvk	IEA	color key
Molecular Function	GO:0016491	oxidoreductase activity	Hmgcr	IEA	color key
Molecular Function	GO:0004631	phosphomevalonate kinase activity	Pmvk	IDA	color key
Molecular Function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	Mvk	IEA	color key
Molecular Function	GO:0030955	potassium ion binding	Acat1	IEA	color key
Molecular Function	GO:0016740	transferase activity	Hmgcs2	IEA	color key
Molecular Function	GO:0016740	transferase activity	Hmgcs1	IEA	color key
Molecular Function	GO:0016740	transferase activity	Mvk	IEA	color key
Molecular Function	GO:0016740	transferase activity	Pmvk	IEA	color key
Molecular Function	GO:0016740	transferase activity	Acat1	IEA	color key
Molecular Function	GO:0016740	transferase activity	Acat2	IEA	color key
Cellular Component	GO:0005737	cytoplasm	Hmgcs1	IEA	color key
Cellular Component	GO:0005737	cytoplasm	Mvk	IEA	color key
Cellular Component	GO:0005737	cytoplasm	Pmvk	IEA	color key
Cellular Component	GO:0005737	cytoplasm	Acat2	IEA	color key
Cellular Component	GO:0005783	endoplasmic reticulum	Hmgcr	IEA	color key
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Hmgcr	IEA	color key
Cellular Component	GO:0016021	integral to membrane	Hmgcr	IEA	color key
Cellular Component	GO:0016020	membrane	Hmgcr	IEA	color key
Cellular Component	GO:0005792	microsome	Hmgcr	IDA	color key
Cellular Component	GO:0005743	mitochondrial inner membrane	Hmgcs2	IDA	color key
Cellular Component	GO:0005743	mitochondrial inner membrane	Acat1	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Hmgcs2	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Acat1	IDA	color key
Cellular Component	GO:0005777	peroxisome	Mvk	IEA	color key
Cellular Component	GO:0005777	peroxisome	Nudt12	IEA	color key
Cellular Component	GO:0005777	peroxisome	Pmvk	IEA	color key
Cellular Component	GO:0005777	peroxisome	Idi1	IEA	color key
Cellular Component	GO:0005777	peroxisome	Hmgcr	IEA	color key
Biological Process	GO:0016117	carotenoid biosynthetic process	Idi1	IEA	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Hmgcs2	IEA	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Hmgcs1	IEA	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Mvk	IEA	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Pmvk	IEA	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Mvd	IEA	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Idi1	IEA	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Hmgcr	IDA	color key
Biological Process	GO:0015936	coenzyme A metabolic process	Hmgcr	IEA	color key
Biological Process	GO:0009790	embryonic development	Hmgcr	IMP	color key
Biological Process	GO:0008299	isoprenoid biosynthetic process	Hmgcs2	IEA	color key
Biological Process	GO:0008299	isoprenoid biosynthetic process	Hmgcs1	IEA	color key
Biological Process	GO:0008299	isoprenoid biosynthetic process	Mvk	IEA	color key
Biological Process	GO:0008299	isoprenoid biosynthetic process	Mvd	IEA	color key
Biological Process	GO:0008299	isoprenoid biosynthetic process	Idi1	IEA	color key
Biological Process	GO:0008299	isoprenoid biosynthetic process	Hmgcr	IEA	color key
Biological Process	GO:0008610	lipid biosynthetic process	Hmgcs2	IEA	color key
Biological Process	GO:0008610	lipid biosynthetic process	Hmgcs1	IEA	color key
Biological Process	GO:0008610	lipid biosynthetic process	Mvk	IEA	color key
Biological Process	GO:0008610	lipid biosynthetic process	Pmvk	IEA	color key
Biological Process	GO:0008610	lipid biosynthetic process	Mvd	IEA	color key
Biological Process	GO:0008610	lipid biosynthetic process	Idi1	IEA	color key
Biological Process	GO:0008610	lipid biosynthetic process	Hmgcr	IEA	color key
Biological Process	GO:0008152	metabolic process	Mvk	IEA	color key
Biological Process	GO:0008152	metabolic process	Acat1	IEA	color key
Biological Process	GO:0008152	metabolic process	Acat2	IEA	color key
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Hmgcr	IGI	color key
Biological Process	GO:0055114	oxidation reduction	Hmgcr	IEA	color key
Biological Process	GO:0016310	phosphorylation	Mvk	IEA	color key
Biological Process	GO:0016310	phosphorylation	Mvd	IEA	color key
Biological Process	GO:0006694	steroid biosynthetic process	Hmgcs2	IEA	color key
Biological Process	GO:0006694	steroid biosynthetic process	Hmgcs1	IEA	color key
Biological Process	GO:0006694	steroid biosynthetic process	Mvk	IEA	color key
Biological Process	GO:0006694	steroid biosynthetic process	Pmvk	IEA	color key
Biological Process	GO:0006694	steroid biosynthetic process	Mvd	IEA	color key
Biological Process	GO:0006694	steroid biosynthetic process	Idi1	IEA	color key
Biological Process	GO:0006694	steroid biosynthetic process	Hmgcr	IEA	color key
Biological Process	GO:0016126	sterol biosynthetic process	Hmgcs2	IEA	color key
Biological Process	GO:0016126	sterol biosynthetic process	Hmgcs1	IEA	color key
Biological Process	GO:0016126	sterol biosynthetic process	Mvk	IEA	color key
Biological Process	GO:0016126	sterol biosynthetic process	Pmvk	IEA	color key
Biological Process	GO:0016126	sterol biosynthetic process	Mvd	IEA	color key
Biological Process	GO:0016126	sterol biosynthetic process	Idi1	IEA	color key
Biological Process	GO:0016126	sterol biosynthetic process	Hmgcr	IEA	color key
Biological Process	GO:0008542	visual learning	Hmgcr	IGI	color key