MGI MouseCyc GO annotations for PWY3DJ-11470

MGI MouseCyc GO annotations for PWY3DJ-11470: sphingosine and sphingosine-1-phosphate metabolism

Roles of genes might be detected in a summary/comparison table of high level GO categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";
Black arrows indicate "regulates";
Green arrows indicate "positively_regulates";
Red arrows indicate "negatively_regulates"

Compare annotations to GO categories for PWY3DJ-11470.

Entry indicates that gene is in this pathway.
Colored entries indicate GO annotation.

Category	ID	Term	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Molecular Function	GO:0005488	binding	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Molecular Function	GO:0003824	catalytic activity	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Cellular Component	GO:0005623	cell	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Cellular Component	GO:0044464	cell part	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Cellular Component	GO:0043226	organelle	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0065007	biological regulation	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0009987	cellular process	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0032502	developmental process	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0008152	metabolic process	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0032501	multicellular organismal process	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0048519	negative regulation of biological process	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0048518	positive regulation of biological process	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0050789	regulation of biological process	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2
Biological Process	GO:0050896	response to stimulus	Asah1	Asah2	Asah3	Ptgr1	Sgpl1	Sgpp1	Sphk1	Sphk2

Full set of annotations for PWY3DJ-11470

Category	ID	Term	Mouse gene	Evidence	Color Key
Molecular Function	GO:0047522	15-oxoprostaglandin 13-oxidase activity	Ptgr1	IEA	color key
Molecular Function	GO:0032440	2-alkenal reductase activity	Ptgr1	IEA	color key
Molecular Function	GO:0005524	ATP binding	Sphk1	IEA	color key
Molecular Function	GO:0005524	ATP binding	Sphk2	IEA	color key
Molecular Function	GO:0005488	binding	Ptgr1	IEA	color key
Molecular Function	GO:0005516	calmodulin binding	Sphk1	ISA	color key
Molecular Function	GO:0016831	carboxy-lyase activity	Sgpl1	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Sgpl1	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Ptgr1	IEA	color key
Molecular Function	GO:0003824	catalytic activity	Sgpp1	IEA	color key
Molecular Function	GO:0017040	ceramidase activity	Asah1	IDA	color key
Molecular Function	GO:0017040	ceramidase activity	Asah2	IDA	color key
Molecular Function	GO:0017040	ceramidase activity	Acer1	IDA	color key
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk2	IDA	color key
Molecular Function	GO:0017050	D-erythro-sphingosine kinase activity	Sphk2	IMP	color key
Molecular Function	GO:0004143	diacylglycerol kinase activity	Sphk1	IEA	color key
Molecular Function	GO:0004143	diacylglycerol kinase activity	Sphk2	IEA	color key
Molecular Function	GO:0003677	DNA binding	Sphk1	ISA	color key
Molecular Function	GO:0016787	hydrolase activity	Asah1	IEA	color key
Molecular Function	GO:0016787	hydrolase activity	Asah2	IEA	color key
Molecular Function	GO:0016787	hydrolase activity	Sgpp1	IEA	color key
Molecular Function	GO:0016787	hydrolase activity	Acer1	IEA	color key
Molecular Function	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	Acer1	IEA	color key
Molecular Function	GO:0016301	kinase activity	Sphk1	IEA	color key
Molecular Function	GO:0016301	kinase activity	Sphk2	IEA	color key
Molecular Function	GO:0016829	lyase activity	Sgpl1	IEA	color key
Molecular Function	GO:0000166	nucleotide binding	Sphk1	IEA	color key
Molecular Function	GO:0000166	nucleotide binding	Sphk2	IEA	color key
Molecular Function	GO:0016491	oxidoreductase activity	Ptgr1	IEA	color key
Molecular Function	GO:0005515	protein binding	Sphk2	ISS	color key
Molecular Function	GO:0030170	pyridoxal phosphate binding	Sgpl1	IEA	color key
Molecular Function	GO:0008481	sphinganine kinase activity	Sphk1	ISA	color key
Molecular Function	GO:0008481	sphinganine kinase activity	Sphk1	ISO	color key
Molecular Function	GO:0008481	sphinganine kinase activity	Sphk2	NAS	color key
Molecular Function	GO:0008117	sphinganine-1-phosphate aldolase activity	Sgpl1	IEA	color key
Molecular Function	GO:0042392	sphingosine-1-phosphate phosphatase activity	Sgpp1	IDA	color key
Molecular Function	GO:0016740	transferase activity	Sphk1	IEA	color key
Molecular Function	GO:0016740	transferase activity	Sphk2	IEA	color key
Molecular Function	GO:0016769	transferase activity, transferring nitrogenous groups	Sgpl1	IEA	color key
Molecular Function	GO:0008270	zinc ion binding	Ptgr1	IEA	color key
Cellular Component	GO:0005737	cytoplasm	Sphk1	ISO	color key
Cellular Component	GO:0005737	cytoplasm	Ptgr1	IEA	color key
Cellular Component	GO:0005829	cytosol	Sphk2	IDA	color key
Cellular Component	GO:0005783	endoplasmic reticulum	Sgpl1	IEA	color key
Cellular Component	GO:0005783	endoplasmic reticulum	Sgpp1	IDA	color key
Cellular Component	GO:0005783	endoplasmic reticulum	Acer1	IDA	color key
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Acer1	IEA	color key
Cellular Component	GO:0000139	Golgi membrane	Acer1	IEA	color key
Cellular Component	GO:0016021	integral to membrane	Sgpl1	IEA	color key
Cellular Component	GO:0016021	integral to membrane	Asah2	IEA	color key
Cellular Component	GO:0016021	integral to membrane	Sgpp1	IEA	color key
Cellular Component	GO:0016021	integral to membrane	Acer1	IEA	color key
Cellular Component	GO:0005764	lysosome	Asah1	IEA	color key
Cellular Component	GO:0016020	membrane	Sgpl1	IEA	color key
Cellular Component	GO:0016020	membrane	Asah2	IEA	color key
Cellular Component	GO:0016020	membrane	Sgpp1	IEA	color key
Cellular Component	GO:0016020	membrane	Acer1	IEA	color key
Cellular Component	GO:0005624	membrane fraction	Sphk1	ISO	color key
Cellular Component	GO:0005624	membrane fraction	Asah2	IDA	color key
Cellular Component	GO:0005624	membrane fraction	Sphk2	IDA	color key
Cellular Component	GO:0005624	membrane fraction	Sgpp1	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Asah2	IDA	color key
Cellular Component	GO:0005886	plasma membrane	Asah2	IEA	color key
Cellular Component	GO:0005625	soluble fraction	Sphk1	ISO	color key
Biological Process	GO:0007205	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	Sphk1	IEA	color key
Biological Process	GO:0007205	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	Sphk2	IEA	color key
Biological Process	GO:0006916	anti-apoptosis	Sphk2	NAS	color key
Biological Process	GO:0006915	apoptosis	Sgpl1	IEA	color key
Biological Process	GO:0006915	apoptosis	Asah2	IEA	color key
Biological Process	GO:0006915	apoptosis	Sgpp1	IDA	color key
Biological Process	GO:0009058	biosynthetic process	Sgpl1	IEA	color key
Biological Process	GO:0001568	blood vessel development	Sphk1	IGI	color key
Biological Process	GO:0001568	blood vessel development	Sphk2	IGI	color key
Biological Process	GO:0007420	brain development	Sphk1	IGI	color key
Biological Process	GO:0007420	brain development	Sphk2	IGI	color key
Biological Process	GO:0019752	carboxylic acid metabolic process	Sgpl1	IEA	color key
Biological Process	GO:0008283	cell proliferation	Asah2	TAS	color key
Biological Process	GO:0046514	ceramide catabolic process	Acer1	IDA	color key
Biological Process	GO:0006672	ceramide metabolic process	Acer1	IEA	color key
Biological Process	GO:0006954	inflammatory response	Sphk1	IMP	color key
Biological Process	GO:0006629	lipid metabolic process	Sgpl1	IEA	color key
Biological Process	GO:0006629	lipid metabolic process	Asah1	IEA	color key
Biological Process	GO:0006629	lipid metabolic process	Asah2	IEA	color key
Biological Process	GO:0006629	lipid metabolic process	Acer1	IEA	color key
Biological Process	GO:0008152	metabolic process	Ptgr1	IEA	color key
Biological Process	GO:0043066	negative regulation of apoptosis	Sphk1	ISO	color key
Biological Process	GO:0055114	oxidation reduction	Ptgr1	IEA	color key
Biological Process	GO:0008284	positive regulation of cell proliferation	Sphk1	IGI	color key
Biological Process	GO:0008284	positive regulation of cell proliferation	Sphk2	IGI	color key
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Sphk1	ISO	color key
Biological Process	GO:0032651	regulation of interleukin-1 beta production	Sphk1	IMP	color key
Biological Process	GO:0019216	regulation of lipid metabolic process	Acer1	IDA	color key
Biological Process	GO:0006669	sphinganine-1-phosphate biosynthetic process	Sphk2	NAS	color key
Biological Process	GO:0006668	sphinganine-1-phosphate metabolic process	Sgpp1	IDA	color key
Biological Process	GO:0006665	sphingolipid metabolic process	Asah2	IEA	color key
Biological Process	GO:0006665	sphingolipid metabolic process	Sgpp1	IDA	color key
Biological Process	GO:0006665	sphingolipid metabolic process	Acer1	IDA	color key
Biological Process	GO:0006670	sphingosine metabolic process	Sphk2	IMP	color key
Biological Process	GO:0006670	sphingosine metabolic process	Sgpp1	IDA	color key