MGI MouseCyc experimental GO annotations for PWY66-5

MGI MouseCyc experimental GO annotations for PWY66-5: superpathway of cholesterol biosynthesis

Roles of genes might be detected in a summary/comparison table of high level GO categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";
Black arrows indicate "regulates";
Green arrows indicate "positively_regulates";
Red arrows indicate "negatively_regulates"

Compare annotations to GO categories for PWY66-5.

Entry indicates that gene is in this pathway.
Colored entries indicate GO annotation.

Category	ID	Term	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Molecular Function	GO:0003824	catalytic activity	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Cellular Component	GO:0005623	cell	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Cellular Component	GO:0044464	cell part	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Cellular Component	GO:0031975	envelope	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Cellular Component	GO:0043226	organelle	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Cellular Component	GO:0044422	organelle part	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0065007	biological regulation	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0009987	cellular process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0032502	developmental process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0040007	growth	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0002376	immune system process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0051179	localization	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0008152	metabolic process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0032501	multicellular organismal process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0048519	negative regulation of biological process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0048518	positive regulation of biological process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0050789	regulation of biological process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0000003	reproduction	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0022414	reproductive process	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2
Biological Process	GO:0050896	response to stimulus	Acat1	Acat2	Cyp51	Dhcr24	Dhcr7	Ebp	Fdft1	Fdps	Fntb	Ggps1	Hmgcr	Hmgcs1	Hmgcs2	Hsd17b7	Idi1	Idi2	Lss	Mvd	Mvk	Nsdhl	Nudt12	Pmvk	Sc4mol	Sc5d	Sqle	Tm7sf2

Full set of annotations for PWY66-5

Category	ID	Term	Mouse gene	Evidence	Color Key
Molecular Function	GO:0000253	3-keto sterol reductase activity	Hsd17b7	IDA	color key
Molecular Function	GO:0047598	7-dehydrocholesterol reductase activity	Dhcr7	IDA	color key
Molecular Function	GO:0003985	acetyl-CoA C-acetyltransferase activity	Acat1	IDA	color key
Molecular Function	GO:0000247	C-8 sterol isomerase activity	Ebp	IDA	color key
Molecular Function	GO:0000247	C-8 sterol isomerase activity	Ebp	IMP	color key
Molecular Function	GO:0004311	farnesyltranstransferase activity	Fntb	IMP	color key
Molecular Function	GO:0004337	geranyltranstransferase activity	Ggps1	IDA	color key
Molecular Function	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	Hmgcr	IDA	color key
Molecular Function	GO:0004496	mevalonate kinase activity	Mvk	IDA	color key
Molecular Function	GO:0004631	phosphomevalonate kinase activity	Pmvk	IDA	color key
Cellular Component	GO:0005783	endoplasmic reticulum	Hsd17b7	IDA	color key
Cellular Component	GO:0005792	microsome	Hmgcr	IDA	color key
Cellular Component	GO:0005743	mitochondrial inner membrane	Hmgcs2	IDA	color key
Cellular Component	GO:0005743	mitochondrial inner membrane	Acat1	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Hmgcs2	IDA	color key
Cellular Component	GO:0005739	mitochondrion	Acat1	IDA	color key
Biological Process	GO:0042987	amyloid precursor protein catabolic process	Dhcr24	IMP	color key
Biological Process	GO:0001568	blood vessel development	Dhcr7	IMP	color key
Biological Process	GO:0030154	cell differentiation	Dhcr7	IMP	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Hsd17b7	IDA	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Dhcr24	IMP	color key
Biological Process	GO:0006695	cholesterol biosynthetic process	Hmgcr	IDA	color key
Biological Process	GO:0008203	cholesterol metabolic process	Nsdhl	IMP	color key
Biological Process	GO:0008203	cholesterol metabolic process	Dhcr24	IMP	color key
Biological Process	GO:0009790	embryonic development	Hmgcr	IMP	color key
Biological Process	GO:0001942	hair follicle development	Nsdhl	IMP	color key
Biological Process	GO:0030097	hemopoiesis	Ebp	IMP	color key
Biological Process	GO:0030324	lung development	Dhcr7	IMP	color key
Biological Process	GO:0030539	male genitalia development	Dhcr24	IMP	color key
Biological Process	GO:0016044	membrane organization	Dhcr24	IMP	color key
Biological Process	GO:0035264	multicellular organism growth	Dhcr7	IMP	color key
Biological Process	GO:0008285	negative regulation of cell proliferation	Fntb	IMP	color key
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Hmgcr	IGI	color key
Biological Process	GO:0031639	plasminogen activation	Dhcr24	IMP	color key
Biological Process	GO:0008284	positive regulation of cell proliferation	Fntb	IMP	color key
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Fntb	IMP	color key
Biological Process	GO:0009791	post-embryonic development	Dhcr7	IMP	color key
Biological Process	GO:0008104	protein localization	Dhcr24	IMP	color key
Biological Process	GO:0042127	regulation of cell proliferation	Dhcr7	IMP	color key
Biological Process	GO:0043588	skin development	Dhcr24	IMP	color key
Biological Process	GO:0016126	sterol biosynthetic process	Ebp	IMP	color key
Biological Process	GO:0016126	sterol biosynthetic process	Dhcr7	IMP	color key
Biological Process	GO:0016125	sterol metabolic process	Dhcr24	IMP	color key
Biological Process	GO:0009888	tissue development	Dhcr24	IMP	color key
Biological Process	GO:0008542	visual learning	Hmgcr	IGI	color key
Biological Process	GO:0042060	wound healing	Fntb	IMP	color key