MGI MouseCyc MP annotations for PWY-841

MGI MouseCyc MP annotations for PWY-841: purine nucleotides de novo biosynthesis II

Roles of genes might be detected in a summary/comparison table of high level MP categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";

Compare annotations to MP categories for PWY-841.

Entry indicates that gene is in this pathway.
Colored entries indicate MP annotation.

ID	Term	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005397	hematopoietic system phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005376	homeostasis/metabolism phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005387	immune system phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005374	lethality-prenatal/perinatal	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005390	skeleton phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0002006	tumorigenesis	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat
MP:0005391	vision/eye phenotype	Adsl	Adss	Adssl1	Atic	Gart	Gmps	Ifnar1	Impdh1	Impdh2	Paics	Pfas	Ppat

Full set of annotations for PWY-841

ID	Term	Mouse gene	Alleles	Background	Color Key
MP:0004392	abnormal CD8-positive T cell physiology	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * 129S6/SvEvTac	color key
MP:0005069	abnormal NK cell physiology	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0003009	abnormal cytokine secretion	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0002376	abnormal dendritic cell physiology	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0002123	abnormal hematopoiesis	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	involves: 129S2/SvPas * BALB/c	color key
MP:0000716	abnormal immune system cell morphology	Impdh1	Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129/Sv * C57BL/6	color key
MP:0001845	abnormal inflammatory response	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0008559	abnormal interferon-gamma secretion	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * 129S6/SvEvTac	color key
MP:0000717	abnormal lymphocyte cell number	Impdh2	Impdh2^tm1Bmi/Impdh2⁺	involves: 129P2/OlaHsd * C57BL/6	color key
MP:0002451	abnormal macrophage physiology	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	involves: 129S2/SvPas * BALB/c	color key
MP:0002451	abnormal macrophage physiology	Ifnar1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1	color key
MP:0004982	abnormal osteoclast morphology	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0005025	abnormal response to infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0001793	altered susceptibility to infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * C57BL/6	color key
MP:0005542	corneal vascularization	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0008045	decreased NK cell number	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	B6.129S2-Ifnar1	color key
MP:0005095	decreased T cell proliferation	Impdh1	Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129/Sv * C57BL/6	color key
MP:0000063	decreased bone density	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0008563	decreased interferon-alpha secretion	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0008563	decreased interferon-alpha secretion	Ifnar1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1	color key
MP:0008565	decreased interferon-beta secretion	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0008565	decreased interferon-beta secretion	Ifnar1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1	color key
MP:0006204	embryonic lethality before implantation	Impdh2	Impdh2^tm1Bmi/Impdh2^tm1Bmi	involves: 129P2/OlaHsd * C57BL/6	color key
MP:0005070	impaired NK cell cytolysis	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0005070	impaired NK cell cytolysis	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key
MP:0005070	impaired NK cell cytolysis	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	B6.129S2-Ifnar1	color key
MP:0008617	increased circulating interleukin-12 level	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * 129S6/SvEvTac	color key
MP:0004499	increased incidence of chemically-induced tumors	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	B6.129S2-Ifnar1	color key
MP:0002021	increased incidence of induced tumors	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	B6.129S2-Ifnar1	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Pjh/Ifnar1^tm1Pjh	involves: 129S2/SvPas * BALB/c	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S2/SvPas * 129S6/SvEvTac	color key
MP:0002418	increased susceptibility to viral infection	Ifnar1	Ifnar1^m1Btlr/Ifnar1^m1Btlr	C57BL/6J-Ifnar1	color key
MP:0003721	increased tumor growth/size	Ifnar1	Ifnar1^tm1Agt/Ifnar1^tm1Agt	B6.129S2-Ifnar1	color key