MGI MouseCyc MP annotations for PWY3DJ-34120

MGI MouseCyc MP annotations for PWY3DJ-34120: leucine degradation

Roles of genes might be detected in a summary/comparison table of high level MP categories.
Complete table of the annotations represented in this image is provided below.
Graph is also available as SVG (requires plug-in)

Gray arrows indicate "is_a";
Blue arrows indicate "part_of";

Compare annotations to MP categories for PWY3DJ-34120.

Entry indicates that gene is in this pathway.
Colored entries indicate MP annotation.

ID	Term	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005375	adipose tissue phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005386	behavior/neurological phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005385	cardiovascular system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005380	embryogenesis phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005378	growth/size phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005376	homeostasis/metabolism phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005373	lethality-postnatal	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005374	lethality-prenatal/perinatal	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005372	life span-post-weaning/aging	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005370	liver/biliary system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005369	muscle phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0003631	nervous system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005367	renal/urinary system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005389	reproductive system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005388	respiratory system phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2
MP:0005393	skin/coat/nails phenotype	Auh	Bcat1	Bcat2	Bckdha	Dbt	Hmgcl	Hmgcll1	Ivd	Mccc1	Mccc2

Full set of annotations for PWY3DJ-34120

ID	Term	Mouse gene	Alleles	Background	Color Key
MP:0000003	abnormal adipose tissue morphology	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005332	abnormal amino acid level	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005332	abnormal amino acid level	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0003860	abnormal carbon dioxide level	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005311	abnormal circulating amino acid level	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0005311	abnormal circulating amino acid level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005311	abnormal circulating amino acid level	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005311	abnormal circulating amino acid level	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001510	abnormal coat appearance	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0006319	abnormal epididymal fat pad morphology	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001432	abnormal food preference	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001406	abnormal gait	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002078	abnormal glucose homeostasis	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0000266	abnormal heart morphology	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0000607	abnormal hepatocyte morphology	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0000607	abnormal hepatocyte morphology	Hmgcl	Hmgcl^tm1Gam/Hmgcl⁺	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0001764	abnormal homeostasis	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0003953	abnormal hormone level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002118	abnormal lipid homeostasis	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001711	abnormal placenta morphology	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0001961	abnormal reflex	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0001757	abnormal urine chemistry	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0000414	alopecia	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0003311	aminoaciduria	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0005156	bradykinesia	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0004893	decreased adiponectin level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001265	decreased body size	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0001262	decreased body weight	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001262	decreased body weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002175	decreased brain weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002702	decreased circulating free fatty acid level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005560	decreased circulating glucose level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002727	decreased circulating insulin level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0003458	decreased circulating ketone body level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005668	decreased circulating leptin level	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0004232	decreased muscle weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005459	decreased percent body fat	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0006207	embryonic lethality during organogenesis	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0003068	enlarged kidney	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005292	improved glucose tolerance	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0005533	increased body temperature	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0003909	increased eating behavior	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0004889	increased energy expenditure	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002891	increased insulin sensitivity	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0003917	increased kidney weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0003960	increased lean body mass	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002981	increased liver weight	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005659	increased resistance to diet-induced obesity	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0002893	ketoaciduria	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0008569	lethality at weaning	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0005202	lethargy	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0003717	pallor	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0001762	polyuria	Bcat2	Bcat2^tm1.2Clyn/Bcat2^tm1.2Clyn	involves: BALB/cJ * C57BL/6J * C57BL/6N	color key
MP:0001732	postnatal growth retardation	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0001732	postnatal growth retardation	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0002082	postnatal lethality	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002083	premature death	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key
MP:0002083	premature death	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0001698	reduced embryo size	Hmgcl	Hmgcl^tm1Gam/Hmgcl^tm1Gam	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	color key
MP:0001921	reduced fertility	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0001954	respiratory distress	Dbt	Dbt^tm1Geh/Dbt^tm1Geh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	color key
MP:0002064	seizures	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0003997	tonic-clonic seizures	Bckdha	Bckdha^{Gt(VICT48)710Lex}/Bckdha^{Gt(VICT48)710Lex}	B6.129S/SvEvBrd-Bckdha	color key
MP:0000746	weakness	Bcat2	Bcat2^m1Ytc/Bcat2^m1Ytc	C57BL/6J	color key